Evidence map›Paper›PMID 41084086›Full record

ArticleActa neuropathologica communications2025

Ablation of progranulin augments microglial activation and accelerates prion progression.

Bei Li, Yiyue Shi, Wenyu Hou, Haoyuan Guan, Jun Li, Tuo Yi, Wei Li, Donglin Cai, Petra Schwarz, Adriano Aguzzi and 1 more

Abstract read
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bei Li *School of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, Fudan University, Dong'An Rd 130, Shanghai, 200032, China.
Yiyue Shi *School of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, Fudan University, Dong'An Rd 130, Shanghai, 200032, China.
Wenyu Hou *School of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, Fudan University, Dong'An Rd 130, Shanghai, 200032, China.
Haoyuan GuanSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, Fudan University, Dong'An Rd 130, Shanghai, 200032, China.
Jun LiSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, Fudan University, Dong'An Rd 130, Shanghai, 200032, China.
Tuo YiSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, Fudan University, Dong'An Rd 130, Shanghai, 200032, China.
Wei LiSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, Fudan University, Dong'An Rd 130, Shanghai, 200032, China.
Donglin CaiSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, Fudan University, Dong'An Rd 130, Shanghai, 200032, China.
Petra SchwarzInstitute of Neuropathology, University of Zurich, Schmelzbergstrasse 12, Zurich, CH-8091, Switzerland.
Adriano AguzziInstitute of Neuropathology, University of Zurich, Schmelzbergstrasse 12, Zurich, CH-8091, Switzerland. Adriano.Aguzzi@uzh.ch.
Caihong ZhuSchool of Basic Medical Sciences, State Key Laboratory of Brain Function and Disorders, Fudan University, Dong'An Rd 130, Shanghai, 200032, China. Caihong_Zhu@fudan.edu.cn.

Funding

Advanced Grant of the European Research Council 670958China Postdoctoral Science Foundation 2021M690036National Natural Science Foundation of China 82101502National Natural Science Foundation of China 82271476Shanghai Pujiang Program 20PJ1401100The Program for Oriental Scholars of Shanghai Universities (Distinguished Professor) TP2022050
6 · The paper itself

Abstract

Mutations or polymorphisms in GRN, encoding the CNS glycoprotein progranulin (PGRN), have been linked to several neurodegenerative diseases. In this study, we explored the role of PGRN in prion diseases. We observed that prion infection upregulated microglial PGRN expression. Following intracerebral inoculation with RML6 prions, Grn

Indexed as

MicrogliaPrion DiseasesProgranulinsAnimalsBrainDisease ProgressionMiceMice, Inbred C57BLMice, KnockoutGrn protein, mouseProgranulinsMicrogliaNeurodegenerationNeuroinflammationPrion diseaseProgranulin

Identifiers

PMID41084086
PMCPMC12519607

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.