Evidence map›Paper›PMID 41084040›Full record

ArticleJournal of nanobiotechnology2025

Neuron-targeted ROS-responsive liposomes for puerarin delivery remodel ischemic microenvironment via microglial modulation and neurovascular regeneration.

Di Chen, Hui Jiang, Lu Sun, Yeltai Nurzat, Haocheng Qin, Zhijie Zhao, Dun Liu, Shaowei Zheng, Liangyu Wang, Yilong Fu and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Hederagenin Attenuates Morphine Addiction via GABAA1-Mediated Modulation of CaAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Insights gained from single-cell sequencing analysis of ischemic stroke.Frontiers in cell and developmental biology · 2026
    Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Di Chen *Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Hui Jiang *Department of Orthopedics, The Affiliated Jinling Hospital of Nanjing Medical University, Nanjing, 210000, China.
Lu Sun *Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai, China.
Yeltai Nurzat *State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, China.
Haocheng Qin *Department of Rehabilitation, Huashan Hospital, Fudan University, Shanghai, China.
Zhijie ZhaoDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Dun LiuDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Shaowei ZhengDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Liangyu WangDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Yilong FuDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Henan JiaoDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Xuqiang ZhuDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Bo SongDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Jinghua YangNHC Key Laboratory of Prevention and Treatment of Cerebrovascular Diseases, Zhengzhou, Henan, China.
Zhiheng LinDepartment of Gynecology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.
Yisheng ChenDepartment of Vascular and Interventional Radiology, Ningde Municipal Hospital of Ningde Normal University, Fujian Key Laboratory of Toxicant and Drug Toxicology, Medical College, Ningde Normal University, Fujian Medical University, Ningde, Fujian, China.
Zhiwen LuoDepartment of Sports Medicine, Huashan Hospital, Fudan University, Shanghai, China. zhiwen.luo_fudan@hotmail.com.
Yuming XuDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China. xuyuming@zzu.edu.cn.
Dongming YanDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China. mrdmyan@163.com.
ZhenZhen ZhaoThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, 250014, China. 2023110795@sdutcm.edu.cn.
Shaohua LiDepartment of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China. 18039673197@163.com.

Funding

China Postdoctoral Science Foundation 2024M752956, 2024M752952Henan Medical Science and Technique Foundation LHGJ20230311, LHGJ20230239Henan Natural Science Foundation 242300421481National Natural Science Foundation of China 82301345, 82401623Postdoctoral Fellowship Program of CPSF GZC20232412
6 · The paper itself

Abstract

Ischemic stroke triggers the "ischemic cascade," which encompasses vascular injury, oxidative stress, inflammatory responses, and mitochondrial dysfunction, ultimately leading to neuronal death and impaired brain function. Conventional pharmacotherapies have specific limitations, such as being restricted by the blood-brain barrier (BBB), causing systemic side effects, and having poor lesion targeting. To tackle the aforementioned challenges, this study developed PUE

Indexed as

Brain IschemiaIsoflavonesLiposomesMicrogliaNeuronsReactive Oxygen SpeciesAnimalsBlood-Brain BarrierDisease Models, AnimalDrug Delivery SystemsInfarction, Middle Cerebral ArteryMaleMiceMice, Inbred C57BLRegenerationIsoflavonesLiposomespuerarinReactive Oxygen SpeciesCerebral ischemiaLiposomeMicroglia polarizationNeuron-targetingNeurovascular regenerationPuerarinROS-responsive

Identifiers

PMID41084040
PMCPMC12519847

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.