Evidence map›Paper›PMID 41083984›Full record

ArticleBMC musculoskeletal disorders2025

Association between blood-derived biological aging and bone mineral density among US adults.

Longyun Wu, Jing Wang, Xiang Liu, Xueji Wang, Xuefeng Yue

Abstract read
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In one paragraph

Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Longyun Wu *Department of Interventional Radiology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Jing Wang *Department of Nuclear Medicine, People's Hospital of Ningxia Autonomous Region, Yinchuan, Ningxia, China.
Xiang LiuDepartment of Endocrine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China.
Xueji WangDepartment of Nuclear Medicine, People's Hospital of Ningxia Autonomous Region, Yinchuan, Ningxia, China.
Xuefeng YueDepartment of Orthopedics, The First People's Hospital of Yinchuan, #2 Liqun Street, Xingqing District, Yinchuan, Ningxia, People's Republic of China. yueyxf1995@163.com.

Funding

Natural Science Foundation of Ningxia Autonomous Region 2021AAC03351Ningxia Science and Technology Benefiting the People Program 2023CMG03013Yinchuan Science and Technology Program 2024SF010
6 · The paper itself

Abstract

objectiveLittle is known regarding the association between biological aging and bone mineral density (BMD). This study aimed to assess the effects of biological aging on BMD in US adults.

methodsThis study included 14,499 adults aged 20 or older from NHANES (2005-2010, 2013-2014, and 2017-2018). Biological aging was assessed using two different approaches: biological age and biological age acceleration. Multiple linear regression was used to investigate the relationship between biological aging and BMD. Generalized additive models and smoothed curve fitting were used to examine the dose-response relationship between biological aging and BMD. Multiple logistic regression was used to investigate the relationship between biological aging and the risk of osteoporosis.

resultsAfter adjusting for potential confounders, our analysis revealed a significant inverse relationship between biological age, biological age acceleration, and BMD at various sites, including the femur neck, total femur, trochanter, and intertrochanter. Furthermore, we observed a significant negative linear correlation between biological age, biological age acceleration, and BMD. Additionally, both biological age and biological age acceleration demonstrated negative associations with the risk of osteoporosis.

conclusionsOur findings suggest a significant negative association between biological aging and BMD in US adults.

Indexed as

AgingBone DensityOsteoporosisAbsorptiometry, PhotonAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysRisk FactorsUnited StatesYoung AdultBiological ageBiological ageingBiological aging accelerationBone mineral density

Identifiers

PMID41083984
PMCPMC12519605

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.