Evidence map›Paper›PMID 41083905›Full record

ArticleJournal of racial and ethnic health disparities2025

Population Attributable Fraction for Cognitive Impairment in Mexican American Older Adults.

Mellanie V Springer, Wen Chang, Steven G Heeringa, Emily M Briceño, Roshanak Mehdipanah, Xavier F Gonzales, Nicholas Hartman, Deborah A Levine, Kenneth M Langa, Darin B Zahuranec and 2 more

Abstract read
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In one paragraph

Article in Journal of racial and ethnic health disparities, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mellanie V SpringerDepartment of Neurology and Stroke Program, University of Michigan, 1500 E. Medical Center drive, Ann Arbor, MI, USA. mvsprin@med.umich.edu.ORCID https://orcid.org/0000-0002-6281-0143
Wen ChangInstitute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Steven G HeeringaInstitute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Emily M BriceñoDepartment of Neurology and Stroke Program, University of Michigan, 1500 E. Medical Center drive, Ann Arbor, MI, USA.
Roshanak MehdipanahDepartment of Health Behavior and Health Equity, University of Michigan, Ann Arbor, MI, USA.
Xavier F GonzalesDepartment of Life Sciences, Texas A&M University, Corpus Christi, TX, USA.
Nicholas HartmanDepartment of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Deborah A LevineDepartment of Neurology and Stroke Program, University of Michigan, 1500 E. Medical Center drive, Ann Arbor, MI, USA.
Kenneth M LangaInstitute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Darin B ZahuranecDepartment of Neurology and Stroke Program, University of Michigan, 1500 E. Medical Center drive, Ann Arbor, MI, USA.
Nelda GarciaDepartment of Neurology and Stroke Program, University of Michigan, 1500 E. Medical Center drive, Ann Arbor, MI, USA.
Lewis B MorgensternDepartment of Neurology and Stroke Program, University of Michigan, 1500 E. Medical Center drive, Ann Arbor, MI, USA.

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
Health and Retirement Study: Harmonized Cognitive Assessment Protocol (HCAP)U01AG058499 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LANGA, KENNETH M · 2018 to 2023
$8.3M
Cognitive impairment in Mexican Americans: a population-based studyR01NS100687 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORGENSTERN, LEWIS B · 2017 to 2021
$7.4M
The Effect of Lower Blood Pressure over the Life Course on Late-life Cognition in Blacks, Hispanics, and Whites (BP-COG)R01NS102715 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEVINE, DEBORAH ALLISON · 2017 to 2021
$3.8M
Brain Attack Surveillance in Corpus Christi (BASIC) ProjectR37NS038916 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LYNDA D LISABETH, LEWIS B MORGENSTERN · 2024 to 2026
$3.7M
Critical Decision Making in Alzheimer's Disease and Related Dementias in Mexican AmericansR01AG069148 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORGENSTERN, LEWIS B, ZAHURANEC, DARIN B · 2020 to 2024
$3.5M
Improving Post-Acute Care to Reduce Ethnic Stroke DisparitiesR01NS107463 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LISABETH, LYNDA D, MORGENSTERN, LEWIS B · 2019 to 2023
$3.3M
Comprehensive Outcome Assessment after Severe Acute Brain Injury: Advanced Symptoms and End-of-Life Care NeedsR01NR019268 · NINR · UNIVERSITY OF WASHINGTON · PI CREUTZFELDT, CLAIRE JOHANNA, ZAHURANEC, DARIN B · 2021 to 2025
$3.0M
Research Network for the Harmonized Cognitive Assessment Protocol (HCAP): Years 6-10U24AG065182 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lindsay C Kobayashi, KENNETH M LANGA · 2022 to 2026
$2.6M
Type 2 Diabetes Mellitus and Vascular Contributions to Cognitive Impairment and Dementia (T2DM-VCID)RF1NS136499 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEVINE, DEBORAH ALLISON · 2024 to 2024
$2.4M
Mild Cognitive Impairment and Alzheimer's Disease and Related Dementias: Cross-national longitudinal prognosis and risk factorsRF1AG088009 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ARCE, MIGUEL, BRICENO, EMILY MARIE · 2024 to 2024
$2.3M
NCI NIH HHS UC2 CA293569NIA NIH HHS K23 AG080035NIA NIH HHS P30 AG024824NIA NIH HHS R01 AG062447NIA NIH HHS R01 AG068410NIA NIH HHS R01 AG069148NIA NIH HHS RF1 AG088009NIA NIH HHS U01 AG009740NIA NIH HHS U01 AG058499NIA NIH HHS U24 AG065182NINDS NIH HHS K01 NS117555NINDS NIH HHS R01 NS100687NINDS NIH HHS R01 NS102715NINDS NIH HHS R01 NS107463NINDS NIH HHS R37 NS038916NINDS NIH HHS RF1 NS136499NINR NIH HHS R01 NR019268
6 · The paper itself

Abstract

backgroundThe contribution of modifiable risk factors to cases of mild cognitive impairment (MCI) and Alzheimer's disease and related dementias (AD/ADRD) among Hispanic/Latin (a,o,x) adults is unclear.

objectiveTo determine the population attributable fraction (PAF), the proportion of MCI and AD/ADRD cases that would be eliminated with elimination of modifiable risk factors.

methodsThis was a cross-sectional analysis nested within a prospective cohort study (2018 - 2023) of Mexican American older adults. Logistic regression estimated the odds of probable MCI or AD/ADRD (defined by education-specific cutoff scores on the Montreal Cognitive Assessment) associated with age, sex, education, medical comorbidities, cigarette smoking, and alcohol consumption. We calculated the PAF for MCI and AD/ADRD associated with individual and combined risk factors.

resultsAmong 1,272 participants, the prevalence of MCI was 48% and of AD/ADRD was 23%. Having no more than a high school education was associated with a PAF for MCI of 17% (95% CI, 10 - 24%) and a PAF for AD/ADRD of 52% (95% CI, 40 - 64%). Heart disease and diabetes were each associated with a PAF for MCI of 5% (95% CI, 3 - 7% and 95% CI, 1 - 10% respectively). A history of stroke was associated with a PAF for AD/ADRD of 7% (95% CI, 3 - 11%). The elimination of all modifiable risk factors was associated with 28% of MCI and 55% of AD/ADRD cases. DISCUSSION: Low educational attainment and cardiovascular comorbidities greatly contribute to cases of MCI and AD/ADRD among Mexican American adults.

Indexed as

Alzheimer's disease and related dementiasEducationMild cognitive impairmentPopulation attributable fraction

Identifiers

PMID41083905
PMCPMC12667309

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.