ArticleNature biotechnology2025
Engineered pattern recognition receptors enhance broad-spectrum plant resistance.
Article in Nature biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
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Who cites it
10 citing papers in PubMed.
- Multiple BnaSOBIR1-Associated Receptor-like Proteins Contribute to Enhanced Resistance toPlants (Basel, Switzerland) · 2026Article
- The C-terminal tail of Cf resistance proteins determines the intensity of the effector-triggered hypersensitive response-related cell death.Plant physiology · 2026Article
- An RLP23/Cf-9Molecular plant pathology · 2026Article
- Diversification and deployment of PRR and NLR immune receptors in potato.The Plant journal : for cell and molecular biology · 2026Review
- Engineering PRRs: A new path to durable resistance.aBIOTECH · 2026Article
- RK3, a G-Type LecRLK, Interacts with FLS2 and BAK1 to Promote flg22-Triggered Immunity.Biology · 2026Article
- Current Understanding of Cell-Surface Immune Receptors for MAMPs and Plant Parasites in the Solanaceae Family.Molecular plant pathology · 2026Review
- Precision targeting: The dawn of artificially customized disease resistance.PLoS pathogens · 2026Review
- Tomato Roots Exhibit Development-Specific Responses to Bacterial-Derived Peptides.Plant, cell & environment · 2025Article
- Rewriting the code of plant immunity.Nature biotechnology · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Conventional plant resistance breeding has primarily focused on intracellular immune receptors, while cell-surface pattern recognition receptors (PRRs) have been underexplored because of their comparatively modest contributions to resistance. However, PRRs offer untapped potential for crop improvement. Here we demonstrate that the Arabidopsis receptor-like protein RLP23, which recognizes molecular patterns from three distinct microbial kingdoms, confers broad-spectrum resistance when introduced into the Solanaceae crop tomato. We also identify the C-terminal domain of RLPs as crucial for ensuring compatibility and efficacy during heterologous expression. Targeted engineering of the C-terminal domain significantly enhances RLP23 and its use, enabling transfer of robust resistance against bacterial, fungal and oomycete pathogens to tomato plants without compromising yield. We extend this RLP engineering strategy to rice and poplar, highlighting its broad applicability. These findings establish a versatile framework for PRR-based engineering, opening additional avenues for sustainable crop protection.
Identifiers
41083902What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.