Evidence map›Paper›PMID 41083882›Full record

SynthesisEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2026

Incidence and risk factors of urinary tract infection in patients with spinal cord injury: a meta-analysis.

Ting Zhang, Yanli Zhao, Jianping Fan, Yijie Shao, Liang Zhao, Junyu Wang

Abstract readMeta-AnalysisSystematic Review
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In one paragraph

Synthesis in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ting ZhangDepartment of Neurosurgery, The Second Affiliated Hospital of Naval Medical University of PLA(Shanghai Changzheng Hospital), Shanghai, China.
Yanli ZhaoDepartment of Urology, The Second Affiliated Hospital of Naval Medical University of PLA(Shanghai Changzheng Hospital), Shanghai, China.
Jianping FanDepartment of Orthopedics, The Second Affiliated Hospital of Naval Medical University of PLA(Shanghai Changzheng Hospital), Shanghai, China.
Yijie ShaoDepartment of Urology, The Second Affiliated Hospital of Naval Medical University of PLA(Shanghai Changzheng Hospital), Shanghai, China.
Liang ZhaoDepartment of Neurosurgery, The Second Affiliated Hospital of Naval Medical University of PLA(Shanghai Changzheng Hospital), Shanghai, China. 15921509289@163.com.
Junyu WangDepartment of Neurosurgery, The Second Affiliated Hospital of Naval Medical University of PLA(Shanghai Changzheng Hospital), Shanghai, China. jerome2008@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeUrinary tract infections (UTI) are a common complication in individuals with spinal cord injury (SCI), substantially impairing their quality of life and elevating mortality risk. Despite existing studies, comprehensive evidence regarding the risk factors for UTI remains insufficient, and the absence of specific preventive strategies presents a serious challenge. This study seeks to investigate how common UTI is among SCI individuals and identify contributing risk factors.

methodsA systematic literature search was performed across multiple databases, including PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP Database, and SinoMed for studies published from inception to September 29, 2024, that focused on UTI in patients with SCI. The Newcastle-Ottawa Scale (NOS) and the Agency for Healthcare Research and Quality (AHRQ) checklist were used to assess the quality of the included studies. STATA version 15.1 was used to pool the UTI incidence among SCI individuals and the odds ratios (OR) with 95% confidence intervals (CI) for relevant risk factors, using both random-effects and fixed-effects models.

results57 studies with 50,533 participants were included. The pooled incidence of UTI was 43% (95% CI: 36%, 50%). Subgroup analysis showed the following incidence rates by region: North America 40% (95% CI: 21%, 61%), South America 40% (95% CI: 31%, 50%), Oceania 50% (95% CI: 28%, 72%), Africa 19% (95% CI: 11%, 28%), Europe 45% (95% CI: 47%, 62%), and Asia 46% (95% CI: 37%, 55%). According to the meta-analysis, the following were determined to be key risk factors for UTI: Age ≥ 60 years (OR = 1.580, 95% CI: 1.286, 1.942); Male gender (OR = 1.707, 95% CI: 1.235, 2.360); Long-term indwelling catheterization (OR = 2.103, 95% CI: 1.565, 2.825) Anemia (OR = 2.128, 95% CI: 1.524, 2.972); Higher level of SCI (OR = 1.627, 95% CI: 1.140, 2.323); Catheter insertion procedure (OR = 5.977, 95% CI: 4.384, 8.149). However, neither intermittent clean catheterization (OR = 1.124, 95% CI: 0.440, 2.869) nor the duration of hospital stay (OR = 1.007, 95% CI: 0.994, 1.020) showed a notable association with the risk of developing UTI.

conclusionThis meta-analysis shows that older age, male gender, duration of indwelling catheterization, anemia, severity of SCI, and invasive catheterization procedures are linked to a heightened risk of UTI among patients with SCI. In contrast, length of hospital stay and intermittent clean catheterization are not significantly related to UTI risk. Increasing awareness of these risk factors and implementing effective preventive strategies are crucial tasks for clinicians and nursing staff in reducing the risk of UTI among SCI patients.

Indexed as

Spinal Cord InjuriesUrinary Tract InfectionsFemaleHumansIncidenceMaleRisk FactorsPatients with spinal cord injuryPrevalenceRisk factorsUrinary tract infection

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.