Evidence map›Paper›PMID 41083872›Full record

ArticleScientific reports2025

Nanoparticle modified paper-based analytical sensor for calcium determination in human nasal secretions and its association with olfactory dysfunction.

Mohamed S Imam, Nasser M Aldekhail, Raghad M A Alhashemi, Afnan M A Alhashmi, Fatimah K S Najmi, Nasaem A Hakami, Reema B S Badyan, Shaden S Alotaibi, Nardeen A S Algethami, Bothinah M N AbuAlhasan and 2 more

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Mohamed S ImamPharmacy Department, Alnahda College, Riyadh, Kingdom of Saudi Arabia.
Nasser M AldekhailDepartment of Pharmacy, College of Pharmacy, Nursing and Medical Sciences, Riyadh Elm University, Riyadh, Saudi Arabia.
Raghad M A AlhashemiCollege of Pharmacy, Jazan University, 82912, Jazan, Saudi Arabia.
Afnan M A AlhashmiCollege of Pharmacy, Jazan University, 82912, Jazan, Saudi Arabia.
Fatimah K S NajmiCollege of Pharmacy, Jazan University, 82912, Jazan, Saudi Arabia.
Nasaem A HakamiCollege of Pharmacy, Jazan University, 82912, Jazan, Saudi Arabia.
Reema B S BadyanCollege of Pharmacy, Taif University, 21944, Taif, Saudi Arabia.
Shaden S AlotaibiCollege of Pharmacy, Taif University, 21944, Taif, Saudi Arabia.
Nardeen A S AlgethamiCollege of Pharmacy, Taif University, 21944, Taif, Saudi Arabia.
Bothinah M N AbuAlhasanCollege of Pharmacy, University of Tabuk, 47512, Tabuk, Saudi Arabia.
Ahmed A M IbrahimDepartment of Otolaryngology, Faculty of Medicine, Al-Azhar University, Damietta, 34518, Egypt. Ahmed.abdelrahmanibrahim@hotmail.com.
Ahmed I ZaghloulDepartment of Otolaryngology, Faculty of Medicine, Al-Azhar University, Damietta, 34518, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Olfactory dysfunction has emerged as an important clinical issue, particularly following the global rise in post-viral anosmia. Recent research suggests an association between altered calcium homeostasis and poor olfactory signaling, but there is no validated method for assessing calcium levels in nasal secretions. Herein, a novel paper-based electrochemical sensor for the direct determination of free calcium ions in nasal secretions, providing potential diagnostic biomarker in olfactory dysfunction. The sensor integrates multi-walled carbon nanotubes, carbon dots synthesized from guava fruit, and the calcium-selective ionophore ETH 1001 to improve conductivity and selectivity. It exhibits a Nernstian response with a slope of 29.14 ± 0.3 mV/decade over a linear range from 10

Indexed as

Biosensing TechniquesCalciumNanoparticlesNasal MucosaOlfaction DisordersPaperAdultElectrochemical TechniquesFemaleHumansMaleMiddle AgedNanotubes, CarbonCalciumNanotubes, CarbonCalcium ionsCarbon nanotubesElectrochemical paper-based sensorNasal secretionsOlfactory dysfunction

Identifiers

PMID41083872
PMCPMC12518631

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.