Evidence map›Paper›PMID 41083825›Full record

ArticleAnnals of surgical oncology2026

Age-Associated Alterations in Cytokine and Extracellular Matrix Remodeling in the Papillary Thyroid Cancer Tumor Microenvironment.

Grace R Thompson, Fahong Yu, Song Han, Gerik Tushoski-Aleman, Jordan A McKean, Steven J Hughes, Aditya S Shirali

Abstract read
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In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Grace R ThompsonDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL, USA.
Fahong YuInterdisciplinary Center for Biotechnology Research (ICBR), University of Florida, Gainesville, FL, USA.
Song HanDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL, USA.
Gerik Tushoski-AlemanDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL, USA.
Jordan A McKeanDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL, USA.
Steven J HughesDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL, USA.
Aditya S ShiraliDepartment of Surgery, University of Florida College of Medicine, Gainesville, FL, USA. Aditya.shirali@surgery.ufl.edu.

Funding

Interdisciplinary Training for Vascular Surgeon ScientistsT32HL160491 · NHLBI · UNIVERSITY OF FLORIDA · PI Scott A Berceli, Gilbert Rivers Upchurch · 2022 to 2026
$1.6M
NHLBI NIH HHS T32 HL160491
6 · The paper itself

Abstract

backgroundAge related changes in the tumor microenvironment (TME) may contribute to cancer progression in older adults. Changes in gene expression with age were analyzed to identify differences in cytokine activity and the extracellular matrix (ECM) in papillary thyroid cancer (PTC). PATIENTS AND

methodsRNA sequencing data of PTC samples were obtained from The Cancer Genome Atlas (TCGA) and divided into four groups: G1 (22-55 years), G2 (55-64 years), G3 (65-74 years), and G4 (≥ 75 years). Disease stages were defined as local (T

resultsOverall, 476 PTC samples were retrieved: G1 (n = 329), G2 (n = 71), G3 (n = 49), and G4 (n = 27). Advanced disease occurred more frequently in older patients (2% in G1 versus 10% in G4, p < 0.0001). Comparing G1 versus G2, G1 versus G3, and G1 versus G4 identified 179, 153, and 254 DEGs, respectively (p

conclusionsExpression of genes associated with the ECM and cytokine receptor binding changed significantly with advanced age, suggesting that age related changes in the TME may contribute to cancer progression.

Indexed as

Biomarkers, TumorCytokinesExtracellular MatrixThyroid Cancer, PapillaryThyroid NeoplasmsTumor MicroenvironmentAdultAgedAge FactorsFemaleFollow-Up StudiesGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPrognosisBiomarkers, TumorCytokinesCytokine receptor bindingDifferential gene expressionExtracellular matrixPapillary thyroid cancerTranscriptional diversityTumor microenvironment

Identifiers

PMID41083825
PMCPMC13107207

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.