Evidence map›Paper›PMID 41083815›Full record

Observational studyJournal of perinatology : official journal of the California Perinatal Association2026

AI to predict extrauterine growth restriction during transitional nutrition of preterm infants: a retrospective study.

Valentina Bozzetti, Linda Greta Dui, Emanuela Zannin, Silvia Riccò, Paola Coglianese, Valeria Cavalleri, Lucia Iozzi, Maria Luisa Ventura, Simona Ferrante

Abstract readObservational Study
In one paragraph

Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Valentina Bozzetti *Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Linda Greta Dui *Department of Electronics, Information and Bioengineering, Politecnico Di Milano, Milan, Italy. lindagreta.dui@polimi.it.ORCID http://orcid.org/0000-0002-6826-3419
Emanuela ZanninFondazione IRCCS San Gerardo dei Tintori, Monza, Italy.ORCID http://orcid.org/0000-0002-5834-3837
Silvia RiccòDepartment of Electronics, Information and Bioengineering, Politecnico Di Milano, Milan, Italy.
Paola CoglianeseFondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Valeria CavalleriFondazione IRCCS San Gerardo dei Tintori, Monza, Italy.ORCID http://orcid.org/0009-0004-0030-6517
Lucia IozziFondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Maria Luisa VenturaFondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Simona FerranteDepartment of Electronics, Information and Bioengineering, Politecnico Di Milano, Milan, Italy.ORCID http://orcid.org/0000-0002-7835-1965

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveExtrauterine growth restriction (EUGR) affects 30-97% of preterm infants and is associated with poor outcomes. We used machine learning (ML) to assess how clinical and nutritional factors, particularly during the transition from parenteral to enteral nutrition, influence EUGR. STUDY

designThis retrospective observational study included 1165 patients (46% with EUGR) born below 33 weeks' gestation or 1500 g. We developed 10 models to predict EUGR combining two sets of features (all and nutritional features only) across five subgroups of patients (all, extremely preterm, very preterm, moderately preterm, small for gestational age).

resultsModel accuracy was 0.71 (F1-score = Recall = AUROC = 0.71, Precision = 0.72) with nutritional features and 0.79 (F1-score = AUROC = 0.79, Precision = 0.80, Recall = 0.79) with all features. Lower EUGR risk was linked to female sex, higher growth velocity, and lipid intake in week one. Influential factors differed by subgroup.

conclusionML models accurately predicted EUGR across preterm subgroups, highlighting the role of early nutritional and clinical variables.

Indexed as

Enteral NutritionFetal Growth RetardationInfant, PrematureMachine LearningParenteral NutritionFemaleGestational AgeHumansInfant, NewbornInfant, Small for Gestational AgeMaleRetrospective Studies

Identifiers

PMID41083815
PMCPMC13008769

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.