Evidence map›Paper›PMID 41083747›Full record

ArticleAdvanced healthcare materials2026

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis.

Sabrina N VandenHeuvel, Lucia L Nash, Abigail J Clevenger, Claudia A Collier, Oscar R Benavides, Sanjana Roy, Brinlee Goggans, Aelita Salikhova, Anvitha Tharakesh, Svasti Haricharan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Biomimetic Scaffold-Based 3D Models for Decoding Cancer Biology and Advancing Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sabrina N VandenHeuvelDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.ORCID 0000-0002-1540-3510
Lucia L NashDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Abigail J ClevengerDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Claudia A CollierDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Oscar R BenavidesDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Sanjana RoyDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Brinlee GoggansDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Aelita SalikhovaDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Anvitha TharakeshDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Svasti HaricharanDepartment of Biology, San Diego State University, San Diego, CA, 92182, USA.
Amber N StratmanDepartment of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Scott KopetzDepartment of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Alex J WalshDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Shreya A RaghavanDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, 77843, USA.ORCID 0000-0002-4631-7762

Funding

Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0M
Regulation of the tumor microenvironment by DNA damage repair proteinsR37CA270362 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Svasti Haricharan · 2023 to 2026
$1.8M
3D Engineered Model of Microscopic Colorectal Cancer Liver Metastasis for Adjuvant Chemotherapy ScreensR37CA269224 · NCI · TEXAS ENGINEERING EXPERIMENT STATION · PI Shreya A. Raghavan · 2023 to 2026
$928k
NCI Cancer Center Support P30 CA91842NCI NIH HHS P30 CA091842NCI NIH HHS R37 CA269224NCI NIH HHS R37CA269224NCI NIH HHS R37 CA270362NCRR NIH HHSNIHNIH Roadmap for Medical ResearchTexas A&M University College of Engineering Horizons Scholarship
6 · The paper itself

Abstract

Recurrent liver-metastatic colorectal cancer contributes to high mortality. Recurrence occurs when dormant, microscopic residual disease survives initial treatment to escape dormancy. In their dormant, microscopic state within the liver, these metastatic lesions are undetectable by clinical diagnostic imaging until they form overt, chemoresistant metastases. Therefore, understanding the molecular mechanisms underlying dormancy in colorectal cancer liver metastases is a significant knowledge gap, motivating the engineering of nuanced in vitro models of disease. The current work presents an engineered model of liver-metastatic colorectal cancer dormancy. Decellularized extracellular matrix (dECM) scaffolds are used to provide microscopic colorectal cancer cell clusters with a biomimetic, 3D liver-specific architecture to colonize. Combined with nutrient deprivation and low dose chemotherapy, liver dECM significantly promotes dormancy, which manifests as slowed proliferation, nutrient/chemo-dependent G1/S and ECM-driven G2/M cell cycle arrest, diminished tumorigenicity, and robust chemotherapy resistance. The engineered dormancy signature is reversible, mimicking dormancy escape. The dECM-based model of engineered dormant colorectal cancer liver metastasis is crucial for advancing knowledge of dormancy induction and reversal, to improve therapeutics and patient survival.

Indexed as

Colorectal NeoplasmsDecellularized Extracellular MatrixExtracellular MatrixLiver NeoplasmsTissue ScaffoldsAnimalsCell Line, TumorCell ProliferationHumansMiceDecellularized Extracellular Matrixcolorectal cancerdormancyextracellular matrixin vitroliver metastasis

Identifiers

PMID41083747
PMCPMC12927541

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.