Evidence map›Paper›PMID 41083723›Full record

ArticleEuropean journal of applied physiology2026

The association of VDR gene polymorphisms with serum vitamin D levels and injury predisposition in elite athletes of Kazakhstan.

Aidana Gabdulkayum, Saya Amangeldikyzy, Sayipzhamal Khassanova, Adil Yerezhepov, Kenes Akilzhanov, Ulan Kozhamkulov, Saule Rakhimova, Ulykbek Kairov, Dauren Yerezhepov, Ainur Akilzhanova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aidana GabdulkayumLaboratory of Genomic and Personalized Medicine, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, 010000, Kazakhstan.
Saya AmangeldikyzyThe National Center for Children's Rehabilitation, Astana, 010000, Kazakhstan.
Sayipzhamal KhassanovaThe National Center for Sports Medicine and Rehabilitation, Almaty, 050000, Kazakhstan.
Adil YerezhepovDepartment of Biotechnology, Al-Farabi Kazakh National University, Almaty, 050000, Kazakhstan.
Kenes AkilzhanovDepartment of Medicine, Semey Medical University, Pavlodar Branch, Pavlodar, 140000, Kazakhstan.
Ulan KozhamkulovLaboratory of Genomic and Personalized Medicine, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, 010000, Kazakhstan.
Saule RakhimovaLaboratory of Genomic and Personalized Medicine, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, 010000, Kazakhstan.
Ulykbek KairovLaboratory of Bioinformatics and Systems Biology, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, 010000, Kazakhstan.
Dauren YerezhepovLaboratory of Genomic and Personalized Medicine, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, 010000, Kazakhstan. dauren.yerezhepov@nu.edu.kz.ORCID http://orcid.org/0000-0002-4161-1348
Ainur AkilzhanovaLaboratory of Genomic and Personalized Medicine, Center for Life Sciences, National Laboratory Astana, Nazarbayev University, Astana, 010000, Kazakhstan. akilzhanova@nu.edu.kz.

Funding

Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan BR24992841Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan BR24993023Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan BR27199879Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan АР19680003
6 · The paper itself

Abstract

purposeThis study aimed to investigate the association between VDR gene polymorphisms and serum vitamin D levels, as well as injury predisposition, in elite athletes from Kazakhstan.

methodsWe recruited 137 elite athletes from Kazakhstan across nine different sports. Serum vitamin D levels were measured by Access 25(OH)D Vitamin D Total assay. The VDR gene polymorphisms were identified using quantitative PCR (qPCR). The association between VDR gene polymorphisms and serum vitamin D levels, as well as injury predisposition, was assessed using statistical methods.

resultsOver 60% of the athletes had vitamin D insufficiency, and 30% were deficient. We found a statistically significant association between vitamin D status and ethnicity (χ

conclusionA high prevalence of insufficient 25-(OH)D levels was observed. Vitamin D insufficiency was associated with ethnicity and age. G/G genotype of VDR TaqI polymorphism is associated with vitamin D insufficiency and increased risk of injuries in athletes of an Asian cohort. These findings may be useful for the development of personalized targeted approaches for diagnostics, nutrition, and injury prevention strategies.

Indexed as

Athletic InjuriesPolymorphism, Single NucleotideReceptors, CalcitriolVitamin DVitamin D DeficiencyAdolescentAdultAthletesFemaleGenetic Predisposition to DiseaseHumansKazakhstanMalePolymorphism, GeneticYoung AdultReceptors, CalcitriolVDR protein, humanVitamin DAthletic performanceSports injuriesVitamin D deficiencyVitamin D receptor polymorphisms

Identifiers

PMID41083723
PMCPMC13013115

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.