Evidence map›Paper›PMID 41083690›Full record

ArticleScientific reports2025

In vitro release kinetics of bioactive compounds (gallic acid, ellagic acid, and eugenol) from chitosan polymer and the bioactivity of herb-loaded chitosan-CuO nanocomposites.

Geethma Ekanayake, Supuni Wijayawardana, Madara Jayanetti, Charitha Thambiliyagodage, Heshan Liyanaarachchi, Amavin Mendis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Geethma EkanayakeDepartment of Applied Sciences, Faculty of Humanities and Sciences, Sri Lanka Institute of Information Technology, Malabe, Sri Lanka.
Supuni WijayawardanaDepartment of Applied Sciences, Faculty of Humanities and Sciences, Sri Lanka Institute of Information Technology, Malabe, Sri Lanka.
Madara JayanettiDepartment of Applied Sciences, Faculty of Humanities and Sciences, Sri Lanka Institute of Information Technology, Malabe, Sri Lanka.
Charitha ThambiliyagodageDepartment of Applied Sciences, Faculty of Humanities and Sciences, Sri Lanka Institute of Information Technology, Malabe, Sri Lanka. charitha.t@sliit.lk.
Heshan LiyanaarachchiDepartment of Applied Sciences, Faculty of Humanities and Sciences, Sri Lanka Institute of Information Technology, Malabe, Sri Lanka.
Amavin MendisDepartment of Applied Sciences, Faculty of Humanities and Sciences, Sri Lanka Institute of Information Technology, Malabe, Sri Lanka.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biological efficacy of nanocomposites comprised of chitosan, CuO nanoparticles, and extracts of Phyllanthus emblica, and Syzygium aromaticum was studied. The study assessed the pH- and ionic strength-responsive controlled release of the bioactive compounds, gallic acid, ellagic acid and eugenol, from the chitosan biopolymer. Release data were fitted into zero-order, first-order, Korsmeyer-Peppas (KP), Peppas-Sahlin (PS), Higuchi, and Hixson-Crowell kinetic models to evaluate the release mechanism. According to KP and PS models (R

Indexed as

ChitosanCopperEllagic AcidEugenolGallic AcidNanocompositesAnti-Bacterial AgentsAntioxidantsDrug LiberationHydrogen-Ion ConcentrationKineticsOsmolar ConcentrationPlant ExtractsSyzygiumAnti-Bacterial AgentsAntioxidantsChitosanCoppercupric oxideEllagic AcidEugenolGallic AcidPlant ExtractsChitosanDrug deliveryEllagic acidEugenolGallic acid

Identifiers

PMID41083690
PMCPMC12518810

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.