ArticleScientific reports2025
Inflammatory and morphological changes in the colon reflect early aging induced by D-galactose in rats.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Article
- Colonic inflammatory response in a D-galactose-induced aging model: elevated IL-1β expression.Journal of molecular histology · 2026Article
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5 authors.
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Abstract
Aging leads to a decline in function and structural changes. To mimic these processes, D-galactose (D-Gal) administration is widely used as a pro-aging model in animal studies due to its reproducibility and practicality. In this study, D-Gal was administered via intraperitoneal injection to induce aging in rats. This study aimed to investigate age-related changes in colon function and structure in an animal model through histological analysis and immunohistochemical assessment of aging biomarkers. Twelve-week-old male Sprague Dawley rats were divided into control and GAL groups. The functional test was performed by measuring the colon transit time duration and faecal output amount. Structural analysis was performed by histological examination using hematoxyllin-eosin staining and immunohistochemistry against p16Ink4A and lamin B1 antibodies. Colon transit time in the GAL group was significantly faster, but fecal pellet output and body weight in the GAL group had lower values. Microscopic examination revealed significant differences (p = 0.00) between the GAL and control groups. The GAL group exhibited mild epithelial (score 1) and muscle tissue damage (score 2), along with leukocyte infiltration (score 3). The immunohistochemistry results showed a significant difference in the GAL group (p < 0.05) for p16Ink4A and lamin B1 antibodies, which confirmed the ongoing aging process. Mild structural and functional changes, accompanied by significant inflammation, suggest that the D-Gal-induced aging model accelerates colon aging.
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