Evidence map›Paper›PMID 41083606›Full record

ReviewNature reviews. Gastroenterology & hepatology2026

Towards a reference cell atlas of liver diversity over the human lifespan.

Sarah A Taylor, Gary D Bader, Sonya MacParland, Alan C Mullen, Tallulah Andrews, Alex G Cuenca, Ramanuj DasGupta, Adam J Gehring, Dominic Grün, Martin Guilliams and 23 more

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Gastroenterology & hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors.

Sarah A TaylorDepartment of Pediatrics, Children's Hospital Colorado and University of Colorado School of Medicine, Aurora, CO, USA.
Gary D BaderThe Donnelly Centre, University of Toronto, Toronto, Ontario, Canada. gary.bader@utoronto.ca.ORCID http://orcid.org/0000-0003-0185-8861
Sonya MacParlandAjmera Transplant Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
Alan C MullenDivision of Gastroenterology, University of Massachusetts Chan Medical School, Worcester, MA, USA. alan.mullen@umassmed.edu.ORCID http://orcid.org/0000-0002-4096-3106
Tallulah AndrewsDepartment of Biochemistry, Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada.ORCID http://orcid.org/0000-0003-1120-2196
Alex G CuencaDepartment of Surgery, Boston Children's Hospital, Boston, MA, USA.
Ramanuj DasGuptaLaboratory of Tumour Evolution, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0001-9015-3729
Adam J GehringToronto Centre for Liver Disease, University Health Network, Toronto, Ontario, Canada.
Dominic GrünWürzburg Institute of Systems Immunology, Max Planck Research Group at the Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-3364-5898
Martin GuilliamsLaboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, VIB Center for Inflammation Research, Ghent, Belgium.
Aliya GulamhuseinToronto Centre for Liver Disease, University Health Network, Toronto, Ontario, Canada.
Neil C HendersonCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-2273-4094
Gideon HirschfieldToronto Centre for Liver Disease, University Health Network, Toronto, Ontario, Canada.
Stacey S HuppertDivision of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0003-3977-8728
Shalev ItzkovitzDepartment of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.ORCID http://orcid.org/0000-0003-0685-2522
Z Gordon JiangDivision of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Georg M LauerLiver Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9792-4271
Ian McGilvrayAjmera Transplant Centre, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada.
Krupa R MysoreTexas Children's Hospital, Baylor College of Medicine, Houston, TX, USA.ORCID http://orcid.org/0000-0001-9890-5518
Carlos J PirolaConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.ORCID http://orcid.org/0000-0001-8234-4058
Gerald QuonDepartment of Molecular and Cellular Biology, University of California, Davis, CA, USA.
Mohammad RahbariDivision of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0003-1133-2134
Aviv RegevBroad Institute, Cambridge, MA, USA.
Amanda RicciutoDivision of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada.
Charlotte L ScottDepartment of Biomedical Molecular Biology, Faculty of Sciences, Ghent University, Ghent, Belgium.
Ankur SharmaGarvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia.
Silvia SookoianConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.ORCID http://orcid.org/0000-0001-5929-5470
Michele M TanaDepartment of Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3665-2735
Sarah A TeichmannDepartment of Medicine, Jeffrey Cheah Biomedical Centre, Cambridge Biomedical Campus, University of Cambridge, Cambridge, UK.
Ludovic VallierBIH Center for Regenerative Therapies, Berlin Institute of Health at Charité, Berlin, Germany.ORCID http://orcid.org/0000-0002-3848-2602
Ioannis S VlachosBroad Institute, Cambridge, MA, USA.
Bruce WangDepartment of Medicine, Division of Gastroenterology, University of California San Francisco, San Francisco, CA, USA.
Mei ZhenDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The goal of the Human Liver Cell Atlas (HLiCA) is to create a comprehensive map that defines the normal functions of diverse liver cell types and their spatial relationships over the human lifespan. This project fits within the goals of the Human Cell Atlas to create comprehensive reference maps of all human cells as a basis for both understanding human health and diagnosing, monitoring and treating disease. Through collection of samples from diverse individuals, data integration across technologies and overcoming liver-specific challenges for experimental methods, the HLiCA will map as many cell types and states as possible in healthy human livers from individuals across all ages and many ancestries. Establishing this HLiCA of healthy livers is a critical step to begin to understand perturbations in disease. The HLiCA will be available on an open-access platform to facilitate data sharing and dissemination. We expect that creation of the HLiCA will help to lay the foundation for new research initiatives to advance our understanding of liver disease, improve methods of tissue engineering, and identify novel prognostic biomarkers and therapies to improve patient outcomes. We describe key experimental and computational challenges to overcome in building the atlas and the potential impact of the atlas on disease research.

Indexed as

Atlases as TopicLiverHepatocytesHumansLiver Diseases

Identifiers

PMID41083606

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.