Evidence map›Paper›PMID 41083565›Full record

ArticleScientific reports2025

Mesenchymal stem cell implantation mitigates ionizing radiation-induced vascular damage in the murine aorta.

Toshio Uchiki, Nobuyuki Hamada, Asuka Fujita, Ki-Ichiro Kawano, Seiko Hirota, Makoto Maeda, Ayano Sasaki, Shogo Nagamatsu, Shinji Yoshinaga, Ayumu Nakashima and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Toshio UchikiDepartment of Regenerative Medicine, Division of Radiation Medical Science, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.ORCID http://orcid.org/0000-0001-9854-2315
Nobuyuki HamadaBiology and Environmental Chemistry Division, Sustainable System Research Laboratory, Central Research Institute of Electric Power Industry (CRIEPI), Chiba, 270-1194, Japan. hamada-n@criepi.denken.or.jp.ORCID http://orcid.org/0000-0003-2518-6131
Asuka FujitaDepartment of Regenerative Medicine, Division of Radiation Medical Science, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.ORCID http://orcid.org/0009-0001-7585-6642
Ki-Ichiro KawanoDepartment of Regenerative Medicine, Division of Radiation Medical Science, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.ORCID http://orcid.org/0000-0003-4585-2365
Seiko HirotaDepartment of Environmetrics and Biometrics, Division of Radiation Basic Science, Research Institute for Radiation Biology and Medicine, Hiroshima University Hospital, Hiroshima, 734-8553, Japan.ORCID http://orcid.org/0000-0002-4384-5893
Makoto MaedaNatural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, 739-8526, Japan.ORCID http://orcid.org/0000-0001-8938-8192
Ayano SasakiDepartment of Plastic Surgery, Hiroshima University Hospital, Hiroshima, 734-8553, Japan.ORCID http://orcid.org/0000-0002-6203-6178
Shogo NagamatsuDepartment of Plastic Surgery, Hiroshima University Hospital, Hiroshima, 734-8553, Japan.ORCID http://orcid.org/0000-0002-8598-8323
Shinji YoshinagaDepartment of Environmetrics and Biometrics, Division of Radiation Basic Science, Research Institute for Radiation Biology and Medicine, Hiroshima University Hospital, Hiroshima, 734-8553, Japan.ORCID http://orcid.org/0000-0002-5328-0240
Ayumu NakashimaDepartment of Nephrology, Graduate School of Medicine, University of Yamanashi, Yamanashi, 409-3898, Japan. a.nakashima@yamanashi.ac.jp.ORCID http://orcid.org/0000-0002-7838-1494
Yukihito HigashiDepartment of Regenerative Medicine, Division of Radiation Medical Science, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. yhigashi@hiroshima-u.ac.jp.ORCID http://orcid.org/0000-0001-5813-3672

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

For preparedness for some scenarios such as unintentional accidents or intentional malicious events, it is of critical importance to develop effective medical countermeasures against normal tissue injury from exposure to ionizing radiation. To this end, agents that are effective when administered after radiation exposure need to be developed. Considering that vascular injury is among the upstream events of radiation toxicity in various tissues, the present study was undertaken to investigate whether post-irradiation implantation of human mesenchymal stem/stromal cells (MSCs) restore vascular injury induced by acute irradiation. MSCs were obtained from human adipose tissue. For in vivo experiments, young adult male C57BL/6J mice (n = 8/group) were received intravenous injection of 5 × 10

Indexed as

AortaMesenchymal Stem CellsMesenchymal Stem Cell TransplantationRadiation Injuries, ExperimentalAnimalsGamma RaysHumansMaleMiceMice, Inbred C57BLRadiation, IonizingIonizing radiationMesenchymal stem cellsVascular damage

Identifiers

PMID41083565
PMCPMC12518571

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.