ArticleNature communications2025
ProFlex as a linguistic bridge for decoding protein dynamics in normal mode analysis.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Computer-Based Design to Improve Bacillus thuringiensis Chitinase for Industrial Applications.ChemistryOpen · 2026Article
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2 authors.
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Abstract
Artificial intelligence is revolutionizing structural bioinformatics, with AlphaFold arguably being the most impactful development to date. The structural atlases generated by these methods present significant opportunities for unraveling biological mysteries but also pose challenges in leveraging such massive datasets effectively. In this work, we explore the dynamic landscape of hundreds of thousands of AlphaFold-predicted structures using normal mode analysis. The resulting data serve to empirically define an alphabet summarizing relative protein flexibility, termed ProFlex. Leveraging ProFlex, we describe the flexibility information space occupied by this massive dataset. We believe leveraging the data compression offered by ProFlex-like approaches opens opportunities for understanding protein function, refining structural predictions, and rendering analyses computationally tractable.
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Registered trials
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