Evidence map›Paper›PMID 41083480›Full record

ArticleNature communications2025

Astrocytes modulate neuronal development by S100A6 signaling.

Valentina Cinquina, Evgenii O Tretiakov, Predrag Kalaba, Alán Alpár, Daniela Calvigioni, Fabiana Piscitelli, Erik Keimpema, Vincenzo Di Marzo, Alexej Verkhratsky, Tibor Harkany

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Valentina CinquinaDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-7365-1395
Evgenii O TretiakovDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-5920-2190
Predrag KalabaInstitute of Biological Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria.
Alán AlpárSE NAP Research Group of Experimental Neuroanatomy, Semmelweis University, Budapest, Hungary.
Daniela CalvigioniDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Fabiana PiscitelliEndocannabinoid Research Group, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR), Pozzuoli, Italy.
Erik KeimpemaDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0002-7555-6762
Vincenzo Di MarzoEndocannabinoid Research Group, Institute of Biomolecular Chemistry (ICB), National Research Council (CNR), Pozzuoli, Italy.
Alexej VerkhratskyFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Tibor HarkanyDepartment of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria. Tibor.Harkany@meduniwien.ac.at.ORCID http://orcid.org/0000-0002-6637-5900

Funding

Austrian Science Fund (Fonds zur Förderung der Wissenschaftlichen Forschung) P 34121-BWellcome Trust
6 · The paper itself

Abstract

Neuronal morphogenesis relies on intercellular signaling. Astrocytes release metabolites, trophic, and guidance factors to promote neuronal maturation. In contrast, the mechanisms by which astrocytes could limit and stabilize neuronal connectivity remain less explored. Here, we find cortical astrocytes to express and release S100A6, a Ca

Indexed as

AstrocytesNeurogenesisNeuronsS100 Calcium Binding Protein A6AnimalsCalcium-Binding ProteinsCerebral CortexFemaleHumansMaleMiceMice, Inbred C57BLPregnancySignal TransductionUnfolded Protein ResponseCalcium-Binding ProteinsS100 Calcium Binding Protein A6

Identifiers

PMID41083480
PMCPMC12518605

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.