ArticleCell death discovery2025
Nobiletin (NOB) nanoparticles ameliorate chronic paradoxical sleep deprivation (PSD)-induced cognitive deficits in rats.
Article in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Nobiletin as a Geroprotective Flavonoid: Mechanisms of Action, Therapeutic Potential, and Challenges of Bioavailability.Antioxidants (Basel, Switzerland) · 2026Review
- The Role of Nuclear Factor Erythroid 2-Related Factor 2 in the Crosstalk Between Oxidative Stress and M1/M2 Microglial Polarization Following Ischemic Stroke.Molecular neurobiology · 2026Review
- Microglial response to sleep deprivation depends on the hippocampal region and paradigm used in adult male mice.Brain, behavior, & immunity - health · 2026Article
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Authors and funding
9 authors.
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Abstract
Nobiletin (NOB), a naturally occurring polymethoxyflavonoid, has been shown to regulate the expression of the clock gene BMAL1. This study aims to explore the impact of NOB nanoparticles on microglial polarization and cognitive impairments resulting from chronic sleep paradoxical deprivation (PSD), as well as the mechanisms involved. Following PSD modeling, rats treated with NOB nanoparticles exhibited significantly improved cognitive performance in behavioral tests. The treatment upregulated the expression of BMAL1, SIRT1, E2F1, and the NAD+/NADH ratio, shifted microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, and enhanced antioxidant defenses. The NAD
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