Evidence map›Paper›PMID 41083444›Full record

ArticleNature communications2025

Structural basis of measles virus polymerase inhibition by nonnucleoside inhibitor ERDRP-0519.

Dong Wang, Fan Bu, Ge Yang, Bin Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Dong Wang *Section of Transcription & Gene Regulation, The Hormel Institute, University of Minnesota, Austin, MN, USA.
Fan Bu *Section of Transcription & Gene Regulation, The Hormel Institute, University of Minnesota, Austin, MN, USA.ORCID http://orcid.org/0000-0002-6965-3072
Ge YangSection of Transcription & Gene Regulation, The Hormel Institute, University of Minnesota, Austin, MN, USA.
Bin LiuSection of Transcription & Gene Regulation, The Hormel Institute, University of Minnesota, Austin, MN, USA. liu00794@umn.edu.ORCID http://orcid.org/0000-0002-6581-780X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ERDRP-0519 is a potent nonnucleoside inhibitor active against measles virus (MeV) and other Morbilliviruses. Here we report cryo-EM structures of the compound bound to MeV polymerase complexes at 2.73 Å and 2.48 Å resolution, revealing a unique binding pocket in the RdRp palm subdomain that overlaps the catalytic GDN motif. These findings clarify the basis of resistance mutations, including W671, and provide a foundation for designing next-generation Paramyxovirus antivirals.

Indexed as

Antiviral AgentsEnzyme InhibitorsMeasles virusRNA-Dependent RNA PolymeraseViral ProteinsBinding SitesCryoelectron MicroscopyDrug Resistance, ViralHumansModels, MolecularMutationAntiviral AgentsEnzyme InhibitorsRNA-Dependent RNA PolymeraseViral Proteins

Identifiers

PMID41083444
PMCPMC12518664

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.