Evidence map›Paper›PMID 41083334›Full record

ArticleAnnals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia2025

The Presence of Both Tumor Spread through Air Spaces and Visceral Pleural Invasion May Increase Tumor Recurrence Risk in Non-Small Cell Lung Cancer.

Joshua R Brady, Brittany Walker, Jocelyn C Zajac, Daniel P McCarthy, James D Maloney, Malcolm M DeCamp, Andrea L Axtell

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Article in Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joshua R BradyDepartment of Surgery, University of Wisconsin Hospitals and Clinics, Madison, WI, USA.
Brittany WalkerDepartment of Surgery, University of Wisconsin Hospitals and Clinics, Madison, WI, USA.
Jocelyn C ZajacDepartment of Surgery, University of Wisconsin Hospitals and Clinics, Madison, WI, USA.
Daniel P McCarthyDivision of Cardiothoracic Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
James D MaloneyDivision of Cardiothoracic Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Malcolm M DeCampDivision of Cardiothoracic Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Andrea L AxtellDivision of Cardiothoracic Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTumor spread through air spaces (STAS) and visceral pleural invasion (VPI) are negative prognostic factors in lung cancer. However, it is unknown whether they have a compounding prognostic effect. Therefore, we analyzed the association between STAS and VPI with overall survival and recurrence.

methodsA retrospective cohort analysis was conducted on 421 adult patients who underwent pulmonary resection for non-small cell lung cancer at an academic institution between 2018 and 2022. Baseline characteristics were compared between patients who had STAS only, VPI only, or both STAS and VPI. Overall survival and cumulative recurrence were compared using the Kaplan-Meier method.

resultsOf the 421 patients who underwent a pulmonary resection, 34 (8%) had both STAS and VPI. Their combined presence was associated with increased smoking pack-years, increased tumor size, and an increased presence of lymphovascular invasion. There was no overall survival difference (p = 0.190) between patients with both STAS and VPI and those with only one feature or neither. However, cumulative incidence of recurrence was increased (p = 0.001) for patients with both.

conclusionThe presence of STAS and VPI was not associated with decreased overall survival; however, their combined presence may have a compounding effect on recurrence risk.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsNeoplasm Recurrence, LocalPleuraAgedFemaleHumansMaleMiddle AgedNeoplasm InvasivenessPneumonectomyRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment Outcomeadenocarcinoma of lungcarcinomalung neoplasmsnon-small cell lung

Identifiers

PMID41083334
PMCPMC12518974

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.