Evidence map›Paper›PMID 41083299›Full record

ArticleBMJ open2025

The leishmaniases in Kenya: a scoping review sub-analysis of diagnostics.

Katherine O'Brien, Grace Grifferty, Hugh Shirley, Santosh George, Abigail Binkley, Adrienne M Orriols, Philip Espinola Coombs, Abigail L Williams, Morgan G Wong, Sophia Roe and 4 more

Abstract readScoping Review
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Katherine O'BrienDepartment of Public Health and Health Sciences, Northeastern University, Boston, Massachusetts, USA obrien.kather@northeastern.edu.ORCID http://orcid.org/0009-0004-7556-0034
Grace GriffertyAfrican Centre for Community Investment in Health, Nginyang, Kenya.
Hugh ShirleyAfrican Centre for Community Investment in Health, Nginyang, Kenya.
Santosh GeorgeKephera Diagnostics, Framingham, Massachusetts, USA.
Abigail BinkleyAfrican Centre for Community Investment in Health, Nginyang, Kenya.
Adrienne M OrriolsAfrican Centre for Community Investment in Health, Nginyang, Kenya.
Philip Espinola CoombsDepartment of Public Health and Health Sciences, Northeastern University, Boston, Massachusetts, USA.
Abigail L WilliamsAfrican Centre for Community Investment in Health, Nginyang, Kenya.
Morgan G WongDepartment of Public Health and Health Sciences, Northeastern University, Boston, Massachusetts, USA.
Sophia RoeDepartment of Public Health and Health Sciences, Northeastern University, Boston, Massachusetts, USA.
Fiona WallaceDepartment of Public Health and Health Sciences, Northeastern University, Boston, Massachusetts, USA.
Kathleen TschoepeDepartment of Bioengineering, Northeastern University, Boston, Massachusetts, USA.
Jason L HirschOhio State University College of Medicine, Columbus, Ohio, USA.
Richard WamaiAfrican Centre for Community Investment in Health, Nginyang, Kenya.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesLeishmaniasis poses a significant public health problem in Kenya, where effective case management and treatment rely on accurate diagnosis. This review aims to summarise the research landscape on leishmaniasis diagnostics in Kenya and identify gaps.

designThis scoping review expands a previously published scoping review on leishmaniasis in Kenya to further analyse studies focusing on diagnostics. The field of diagnostics was chosen because of recent pushes for novel tools and because of the role timely diagnosis plays in disease elimination. A comprehensive search of PubMed, Embase via Embase.com, Web of Science Core Collection, the Cochrane Library, ClinicalTrials.gov, WHO ICTRP and the Pan African Clinical Trials Registry was conducted, covering studies up to 5 January 2024.

resultsAfter dual, blind screening with conflict resolution by a third reviewer, 41 studies were included in the review. These studies examined a range of diagnostic tools; however most were assessed in one or few studies, and none evaluated real-time PCR. Additional gaps in the research landscape include a lack of diagnostics for cutaneous leishmaniasis and post-kala-azar dermal leishmaniasis in Kenya, outdated literature surrounding the Direct Agglutination Test and randomised trials for any diagnostic tool.

conclusionsFuture research should focus on solidifying the validity and reliability of diagnostic tools in the Kenyan context and updating previous work.

Indexed as

LeishmaniasisHumansKenyaLeishmaniasis, CutaneousDiagnostic microbiologyMolecular diagnosticsNeglected DiseasesReview

Identifiers

PMID41083299
PMCPMC12519670

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.