Evidence map›Paper›PMID 41083292›Full record

ArticleBMJ open2025

Sedating with volatile anaesthetics for COVID-19 and non-COVID-19 acute hypoxaemic respiratory failure patients in ICU (SAVE-ICU): protocol for a randomised clinical trial.

Angela Jerath, Marat Slessarev, Claudio Martin, Frederick D'Aragon, Francois Martin Carrier, Janek Senaratne, Hilary Meggison, Jonathan Hooper, Yiorgos Alexandros Cavayas, Ewan C Goligher and 9 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04415060 (SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04415060 phase3active not recruitingnot on this map

SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival. Multicentre Open-label, Pragmatic, Randomized Controlled Trial and a Parallel Prospective (Non-randomized) Cohort Study

TypeinterventionalSponsorSunnybrook Health Sciences CentreRan2020 to 2027Enrolled800ConditionsCovid19, Hypoxic Respiratory FailureArmsIsoflurane Inhalant Product, Sevoflurane inhalant product
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Angela JerathDepartment of Anesthesiology and Pain Medicine, Sunnybrook Research Institute, Toronto, Ontario, Canada Angela.Jerath@utoronto.ca.ORCID http://orcid.org/0000-0002-1557-1151
Marat SlessarevLawson Health Research Institute, London, Ontario, Canada.
Claudio MartinLawson Health Research Institute, London, Ontario, Canada.
Frederick D'AragonAnesthesiology, Universite de Sherbrooke Faculte de medecine et des sciences de la sante, Sherbrooke, Quebec, Canada.ORCID http://orcid.org/0000-0003-1323-0449
Francois Martin CarrierAnesthesiology, Centre Hospitalier de l'Universite de Montreal, Montreal, Québec, Canada.ORCID http://orcid.org/0000-0003-0310-0616
Janek SenaratneGrey Nuns Community Hospital, Edmonton, Alberta, Canada.
Hilary MeggisonThe Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Jonathan HooperThe Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Yiorgos Alexandros CavayasHopital du Sacre-Coeur de Montreal, Montreal, Québec, Canada.
Ewan C GoligherToronto General Hospital, Toronto, Ontario, Canada.
Etienne J CoutureIUCPQ-ULaval, Québec City, Quebec, Canada.
Ian RandallToronto Western Hospital, Toronto, Ontario, Canada.
Roupen HatzakorzianRoyal Victoria Hospital, Montreal, Québec, Canada.
Michael JackaUniversity of Alberta Hospital, Edmonton, Alberta, Canada.
Jeanine Wiener-KronishMassachusetts General Hospital, Boston, Massachusetts, USA.
Zhongcong XieMassachusetts General Hospital, Boston, Massachusetts, USA.
Ruxandra L PintoSunnybrook Research Institute, Toronto, Ontario, Canada.
Brian CuthbertsonDepartment of Anesthesiology and Pain Medicine, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada.
SAVE-ICU Investigators and the Canadian Critical Care Trials Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInhaled anaesthetics can be used in mechanically ventilated critically ill patients to provide sedation. This approach to sedation potentially improves patient and health system outcomes, but further supportive evidence is needed. The objective of the SAVE-ICU clinical trial is to compare the effectiveness of inhaled versus intravenous sedation in ventilated adults with acute hypoxaemic respiratory failure. METHODS AND ANALYSIS: SAVE-ICU is a multicentre, open-label, pragmatic, randomised controlled trial conducted in 15 intensive care units (ICUs) in Canada and the USA. Eligible patients include mechanically ventilated and sedated adults with acute hypoxemic respiratory failure from COVID-19 or non-COVID causes with PaO ETHICS AND DISSEMINATION: The protocol was approved by all hospital ethics committees and by Health Canada. Informed consent will be obtained from substitute decision makers or deferred consent (as permitted by site ethics board). Trial findings will be shared at the end of the study using peer-review publications, conference presentations and social media as part of the trial knowledge translation plan. TRIAL REGISTRATION NUMBER: NCT04415060.

Indexed as

Anesthetics, InhalationCOVID-19Hypnotics and SedativesHypoxiaRespiration, ArtificialRespiratory InsufficiencyCanadaHumansIntensive Care UnitsMulticenter Studies as TopicPragmatic Clinical Trials as TopicRandomized Controlled Trials as TopicSARS-CoV-2United StatesAnesthetics, InhalationHypnotics and SedativesAdult intensive & critical careANAESTHETICSCOVID-19HypoxiaINTENSIVE & CRITICAL CARERandomized Controlled Trial

Identifiers

PMID41083292
PMCPMC12519663

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.