Evidence map›Paper›PMID 41082983›Full record

Trial reportThe Journal of nutrition2025

Association Between Diet Patterns of Human Infants and Growth Differs Across Randomized Formula Groups in the First 18.5 Months.

Jessica E Decker, Julie A Mennella, Benjamin C Brewer, Shannon M Robson, Amy E Millen, Michelle T Delahanty, Alissa D Smethers, Jillian C Trabulsi

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01700205 (Impact of Diet Composition on Energy Balance and Satiety During Infancy), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01700205 nacompletednot on this map

Impact of Diet Composition on Energy Balance and Satiety During Infancy

TypeinterventionalSponsorMonell Chemical Senses CenterRan2012 to 2016Enrolled113ConditionsDevelopmentArmsType of Formula
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jessica E DeckerDepartment of Behavioral Health and Nutrition, College of Health Sciences, University of Delaware, Newark, DE, United States; Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Julie A MennellaMonell Chemical Senses Center, Philadelphia, PA, United States.
Benjamin C BrewerCollege of Science, Center for Biostatistics and Health Data Science, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.
Shannon M RobsonDepartment of Behavioral Health and Nutrition, College of Health Sciences, University of Delaware, Newark, DE, United States.
Amy E MillenDepartment of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo, NY, United States.
Michelle T DelahantyDepartment of Behavioral Health and Nutrition, College of Health Sciences, University of Delaware, Newark, DE, United States.
Alissa D SmethersMonell Chemical Senses Center, Philadelphia, PA, United States.
Jillian C TrabulsiDepartment of Behavioral Health and Nutrition, College of Health Sciences, University of Delaware, Newark, DE, United States. Electronic address: trabulsi@udel.edu.

Funding

Impact of diet composition during infancy on energy balance, satiety and growthR01HD072307 · NICHD · MONELL CHEMICAL SENSES CENTER · PI MENNELLA, JULIA ANNE, TRABULSI, JILLIAN CHRISTINE · 2012 to 2016
$2.7M
Secondary Analyses of RCT Data on Infant Formula and Nutritional ProgrammingR03HD094908 · NICHD · MONELL CHEMICAL SENSES CENTER · PI MENNELLA, JULIA ANNE, TRABULSI, JILLIAN CHRISTINE · 2018 to 2019
$173k
NICHD NIH HHS R01 HD072307NICHD NIH HHS R03 HD094908
6 · The paper itself

Abstract

backgroundThe composition of the formula fed to infants and the velocity of weight gain during infancy can impact later weight status. However, whether patterns of food and beverage intake during the complementary feeding period affect this relationship remains unclear.

objectivesTo identify patterns of complementary feeding (primary aim) and to examine how these diet patterns, along with infant formula composition and early weight gain velocity, influence weight status over time (secondary aim).

methodsDiet records were collected monthly from 0.5 to 12.5 mo and again at 18.5 mo (n = 80) as part of a trial involving healthy infants randomly assigned to receive either cow milk formula (CMF) or an isocaloric extensively hydrolyzed protein formula (EHF). Foods and beverages were assigned to mutually exclusive What We Eat in America food categories, and intake at each age was standardized for body weight (g/kg). Diet patterns were derived using principal component analysis. Generalized estimating equations examined the independent and interactive effects of formula type (fixed effect), rapid weight gain (RWG) category (rapid/nonrapid; fixed effect), and infant diet patterns (time-varying effect) on weight-for-length Z-score (WLZ) over time.

resultsOver the first 18.5 mo, 4 diet patterns were identified: (PC1) "infant formula;" (PC2) "low-sugar cereal, not fried potatoes, grain mixed dishes, fruit, vegetables, meat mixed dishes, 100% fruit juice;" (PC3) "milk, pizza, water, high-sugar cereal and snack/meal bars;" (PC4) "fried poultry, bakery products, fried potatoes, starchy vegetables." Over time, the effect of RWG category on WLZ was significant for the CMF (χ

conclusionsThe prolonged feeding of CMF, but not EHF, during complementary feeding was associated with greater WLZ in the first 18.5 mo. This trial was registered at clinicaltrials.gov as NCT01700205 (https://clinicaltrials.gov/study/NCT01700205).

Indexed as

DietFeeding BehaviorInfant FormulaInfant Nutritional Physiological PhenomenaAnimalsDiet RecordsFemaleHumansInfantMaleMilkWeight Gaincomplementary dietcow milk formuladiet patternsextensive protein hydrolysate formulaprincipal component analysistoddlerstransition diet

Identifiers

PMID41082983
PMCPMC12699487

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.