Evidence map›Paper›PMID 41082979›Full record

Trial reportThe Journal of nutrition2025

Dietary Polyphenols and Inflammatory Markers in Rural Adult Women in Puno, Peru.

Emily P Laveriano-Santos, Carla Tarazona-Meza, Gary Malpartida, Dana B Barr, Kendra N Williams, Josiah L Kephart, Laura Nicolaou, Magdalena Fandiño-Del-Rio, Suzanne Simkovich, Marilu Chiang and 4 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Emily P Laveriano-SantosBarcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain.
Carla Tarazona-MezaDepartment of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States; Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, MD, United States.
Gary MalpartidaBiomedical Research Unit, A.B. PRISMA, Lima, Perú.
Dana B BarrDepartment of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States.
Kendra N WilliamsDepartment of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States; Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, MD, United States.
Josiah L KephartDepartment of Environmental and Occupational Health, Dornsife School of Public Health, Drexel University, Philadelphia, PA, United States.
Laura NicolaouCenter for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, MD, United States; Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, United States; Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Magdalena Fandiño-Del-RioCenter for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, MD, United States; Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Suzanne SimkovichCenter for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, MD, United States; Division of Pulmonary, Critical Care and Sleep Medicine, MedStar Georgetown University Hospital, Washington DC, United States; Division of Healthcare Delivery Research, MedStar Health Research Institute, Washington DC, United States.
Marilu ChiangBiomedical Research Unit, A.B. PRISMA, Lima, Perú.
Kirsten KoehlerDepartment of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States.
Rosa M Lamuela-RaventósCentro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain; Polyphenol Research Group, Department of Nutrition, Food Science and Gastronomy, School of Pharmacy and Food Sciences, INSA, University of Barcelona, Barcelona, Spain.
William CheckleyCenter for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, MD, United States; Division of Pulmonary and Critical Care Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, United States. Electronic address: wcheckl1@jhmi.edu.
Cardiopulmonary Outcomes and Household Air Pollution (CHAP) trial investigators

Funding

Building U.S. Research Capacity Through International Environmental Health Science on Air Pollution, Cardiorespiratory Disease, and Alzheimer’s Disease (Research U01)U01TW010107 · FIC · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI William Checkley, Stella Maria Hartinger · 2015 to 2026
$3.5M
GEOHealth Hub Peru: Building U.S. Research Capacity Through International Environmental Health Science on Air Pollution, Cardiorespiratory Disease, and Alzheimer’s Disease (Research Training U2R)U2RTW010114 · FIC · EMORY UNIVERSITY · PI William Checkley, Stella Maria Hartinger · 2015 to 2026
$3.3M
Research training in chronic, non-communicable respiratory diseases in PeruD43TW011502 · FIC · JOHNS HOPKINS UNIVERSITY · PI CHECKLEY, WILLIAM, HARTINGER, STELLA MARIA · 2019 to 2023
$1.2M
FIC NIH HHS D43 TW011502FIC NIH HHS U01 TW010107FIC NIH HHS U2R TW010114
6 · The paper itself

Abstract

backgroundDietary polyphenols are bioactive compounds credited with health protection and reducing inflammation. Evidence on their effects is limited in low- and middle-income countries, especially among rural populations.

objectivesTo evaluate the association between dietary polyphenols intake and markers of inflammation and endothelial adhesion over 12 mo of follow-up among rural adult women participating in the Cardiopulmonary Outcomes and Household Air Pollution randomized controlled trial.

methodsWe used data at baseline and 12-mo visit in 100 healthy women aged 25-64 y living in rural communities in Puno, Peru. We assessed dietary intake using 24-h dietary recalls and measured inflammatory cytokines [interleukin (IL)-10, IL-6, IL-1β, C-reactive protein, tumor necrosis factor-α] and endothelial adhesion (vascular cell adhesion protein-1, intercellular adhesion molecule-1) biomarkers in dried blood spots using immunoassay analyses. We quantified polyphenol intake using the Phenol-Explorer database. We used multivariable linear regression to assess the association between changes (12-mo of follow-up minus baseline) in dietary polyphenols intake, and inflammatory and endothelial adhesion markers at 12-mo.

resultsAt baseline, mean (±standard deviation) participant age was 49 ± 10 y, mean total polyphenol intake was 335 ± 193 mg/d, and mean phenolic acids intake was 195 ± 80 mg/d. Lower IL-1β concentrations at 12-mo were associated with higher energy-adjusted phenolic acid intake [adjusted mean difference -0.35 pg/mL per mg/d; 95% confidence interval (CI): -0.63, -0.07]. In contrast, higher anti-inflammatory cytokines IL-10 concentrations at 12 mo were associated with higher energy-adjusted intake of stilbenes (0.42 pg/mL per mg/d; 95% CI: 0.18, 0.66) and other polyphenols (0.28 pg/mL per mg/d; 95% CI: 0.10, 0.46).

conclusionsHigher polyphenol intake, particularly phenolic acids and stilbenes, was associated with an improved anti-inflammatory profile in rural women.

Indexed as

DietInflammationPolyphenolsRural PopulationAdultBiomarkersC-Reactive ProteinCytokinesFemaleFollow-Up StudiesHumansIntercellular Adhesion Molecule-1Middle AgedPeruVascular Cell Adhesion Molecule-1BiomarkersC-Reactive ProteinCytokinesIntercellular Adhesion Molecule-1PolyphenolsVascular Cell Adhesion Molecule-1antioxidantsbioactive compoundshigh altitudeinterleukinsPeruphytochemicals(poly)phenols

Identifiers

PMID41082979
PMCPMC13639623

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.