Evidence map›Paper›PMID 41082949›Full record

ReviewNeurobiology of disease2025

Hippocampal neural circuit mechanisms in Alzheimer's disease revealed by viral-genetic circuit mapping.

Qiao Ye, Gocylen Gast, Todd C Holmes, Xiangmin Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurobiology of disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qiao YeDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697, USA.
Gocylen GastDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697, USA.
Todd C HolmesDepartment of Physiology and Biophysics, School of Medicine, University of California, Irvine, CA 92697, USA; Center for Neural Circuit Mapping, University of California, Irvine, CA 92697, USA.
Xiangmin XuDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA 92697, USA; Center for Neural Circuit Mapping, University of California, Irvine, CA 92697, USA; Department of Biomedical Engineering, Samueli School of Engineering, University of California, Irvine, CA 92697, USA; Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, CA 92697, USA. Electronic address: xiangmix@uci.edu.

Funding

UV to blue neuronal phototransduction mechanismsR35GM127102 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Todd C Holmes · 2018 to 2026
$4.4M
Genetically engineered anterograde monosynaptic viral tracers for multi-species neural circuit analysisRF1MH120020 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI HORWITZ, GREGORY D, SANDRI-GOLDIN, ROZANNE M · 2019 to 2019
$4.3M
Neural circuit mechanisms underlying AD-related memory impairmentsRF1AG065675 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI XU, XIANGMIN · 2020 to 2020
$1.9M
NIA NIH HHS RF1 AG065675NIGMS NIH HHS R35 GM127102NIMH NIH HHS RF1 MH120020
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with growing major health impacts in countries with aging populations. Existing therapeutic approaches that have been based on neurochemical and neuropathological findings are largely ineffective. This lack of progress suggests we require a new framework for future AD therapies. The examination of neural circuit mechanisms in AD mouse models is an emerging focus for identifying new AD treatment strategies. We now know there are neural circuit-level maladaptive alterations in AD brains, some of which appear very early in the disease process before neuropathological features are detectable. Recent advancements in viral-genetic technologies allow us to quantitatively map the cell-type-specific neural circuit connections in AD mouse models. Monosynaptic rabies virus mapping reveals age-progressive changes in both long-range and local hippocampal neural circuit connectivity in AD mouse models - and provides explanations for human AD behavioral defects, such as sex differences and higher level visual deficits. These recent developments in neural circuits level concepts and technology present new opportunities for studying AD pathogenesis for early identification of the disease and for developing novel therapeutic interventions.

Indexed as

Alzheimer DiseaseHippocampusNerve NetAnimalsDisease Models, AnimalHumansMiceNeural PathwaysRabies virusAlzheimer's diseaseNeural circuit tracingRabiesViral-genetic tools

Identifiers

PMID41082949
PMCPMC12908724

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.