ArticleNature2025
Host cell Z-RNAs activate ZBP1 during virus infections.
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Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
–field-weighted citation impact
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Who cites it
27 citing papers in PubMed.
- Biological consequences of Z-nucleic acid sensing by ZBP1 and ADAR1.RNA biology · 2026Review
- Role of PANoptosis in cancer: molecular mechanisms and therapeutic insights.Archives of toxicology · 2026Review
- ZBP1 specifically binds pre-formed Z-RNA, limiting its potential pool of nucleic acid ligands compared to ADAR1.Nucleic acids research · 2026Article
- ZBP1-mediated Treg cell dysfunction exacerbates neuroimmune dysregulation in Alzheimer's disease under metabolic stress.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Flipons, Noncoding Transcripts and Retroelements: A Universal Host Defense.International journal of molecular sciences · 2026Review
- Z-Nucleic Acid-Binding Protein (ZBP)1 (DAI/DLM1) Regulation in Antiviral Cell Death Pathways.Pathogens (Basel, Switzerland) · 2026Review
- Z-DNA-associated genomic instability in the human pangenome.Research square · 2026Article
- Loss of cellular RNA homeostasis contributes to MDA5 activation during virus infection.Nature immunology · 2026Article
- ZBP1 in Neuroinflammation and Neurodegeneration: Z-Nucleic-Acid Sensing, RHIM Signalling and Therapeutic Targeting.International journal of molecular sciences · 2026Review
- Structural and molecular principles of DAMP biology.Nature structural & molecular biology · 2026Review
- Z-DNA-induced genomic instability in the human pangenome.Research square · 2026Article
- Review
- ZBP1-driven pyroptosis-associated alveolar macrophages exacerbate epithelial dysfunction in sepsis.Cell death & disease · 2026Article
- Review
- Z-nucleic acid-mediated PANoptosis in infection, inflammation, and cancer.Communications biology · 2026Review
- RNAs anchoring replication complex control initiation and firing of DNA replication.Nature communications · 2026Article
- Zα and Zβ domains of ADAR1 and ZBP1 bind G-quadruplexes with nanomolar affinities, establishing Zβ as a G-quadruplex-specific domain.Nucleic acids research · 2026Article
- Cryo-EM structures of anti Z-DNA antibodies in complex with antigen reveal distinct recognition modes of a left-handed geometry.Nucleic acids research · 2026Article
- Multiomic Profiling Reveals the Regulation of Many Immune-Related Genes by PU.1 in Porcine Alveolar Macrophages.Animals : an open access journal from MDPI · 2026Article
- Article
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Authors and funding
27 authors.
Chaoran Yin *Center for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Aleksandr Fedorov *Laboratory of Bioinformatics, Faculty of Computer Science, National Research University Higher School of Economics, Moscow, Russia.ORCID 0000-0002-8829-3447
Hongyan Guo *Department of Microbiology and Immunology, Louisiana State University Health Shreveport, Shreveport, LA, USA.
Jeremy Chase CrawfordDepartment of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-4096-6048
Claire RousseauInstitute for Virology and Immunobiology, Julius-Maximilians-Universität-Würzburg, Würzburg, Germany.ORCID 0000-0001-6441-6919
Xiao ZhongLaboratory of Hepatic AI Translation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Riley M WilliamsCenter for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Avishekh GautamCenter for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Heather S KoehlerSchool of Molecular Biosciences, Washington State University, Pullman, WA, USA.
Adam W WhisnantInstitute for Virology and Immunobiology, Julius-Maximilians-Universität-Würzburg, Würzburg, Germany.
Thomas HennigInstitute for Virology and Immunobiology, Julius-Maximilians-Universität-Würzburg, Würzburg, Germany.
Anna RozinaMedical Research Council Translational Immune Discovery Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-2669-4464
Yuhan ZhongLaboratory of Hepatic AI Translation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Shuangjuan LvLaboratory of Hepatic AI Translation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Valter BergantInstitute of Virology, School of Medicine & Health, Technical University of Munich, Munich, Germany.ORCID 0000-0003-3458-9506
Shuqi WangDepartment of Microbiology and Immunology, Louisiana State University Health Shreveport, Shreveport, LA, USA.ORCID 0009-0003-3561-4694
Peter DrögeSchool of Biological Sciences, Nanyang Technological University, Singapore, Singapore.
Sven MillerCenter for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA.
Maria PoptsovaLaboratory of Bioinformatics, Faculty of Computer Science, National Research University Higher School of Economics, Moscow, Russia.ORCID 0000-0002-7198-8234
Jan RehwinkelMedical Research Council Translational Immune Discovery Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Andreas PichlmairInstitute of Virology, School of Medicine & Health, Technical University of Munich, Munich, Germany.ORCID 0000-0002-0166-1367
Edward S MocarskiDepartment of Microbiology and Immunology, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Paul G ThomasDepartment of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-7955-0256
Lars DölkenInstitute for Virology and Immunobiology, Julius-Maximilians-Universität-Würzburg, Würzburg, Germany. doelken.lars@mh-hannover.de.ORCID 0000-0002-4651-3544
Ting ZhangLaboratory of Hepatic AI Translation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, People's Republic of China. tingzhang923@wchscu.cn.
Alan HerbertLaboratory of Bioinformatics, Faculty of Computer Science, National Research University Higher School of Economics, Moscow, Russia. alan.herbert@insideoutbio.com.ORCID 0000-0002-0093-1572
Siddharth BalachandranCenter for Immunology, Fox Chase Cancer Center, Philadelphia, PA, USA. Siddharth.balachandran@fccc.edu.ORCID 0000-0003-2084-1803
Funding
WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8MProject 4-Tracking cytomegalovirus-primed long-lived NK cells in salivary glandP20GM134974 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI ANDREW D YUROCHKO · 2021 to 2026
$15.0MMechanism, Function, and Exploitation of Influenza A Virus-Activated Cell DeathR01AI135025 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI BALACHANDRAN, SIDDHARTH · 2017 to 2025
$6.8MTargeting RIPK3 in Flu-Associated Lung InjuryR01AI144400 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI BALACHANDRAN, SIDDHARTH, CUNY, GREGORY D · 2019 to 2023
$3.6MRole of ZBP1 in pathogenesis of Salmonella biofilmsR01AI171568 · NIAID · RESEARCH INST OF FOX CHASE CAN CTR · PI SIDDHARTH BALACHANDRAN, Cagla Tukel · 2023 to 2026
$3.4MA protective role for gamma delta T cells in respiratory infectionR01AI121832 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI THOMAS, PAUL G. · 2016 to 2020
$2.2MInterferon Activated Necroptosis as a New Therapeutic Avenue for Kidney CancerR01CA168621 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI BALACHANDRAN, SIDDHARTH · 2014 to 2018
$1.9MBoosting Oncolytic HSV Immunotherapy by Enabling NecroptosisR21CA303392 · NCI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI GUO, HONGYAN · 2025 to 2025
$416kRole of receptor-interacting serine/threonine-protein kinase 3 (RIPK3) in Herpes Simplex Virus (HSV) EncephalitisR21AI175590 · NIAID · LOUISIANA STATE UNIV HSC SHREVEPORT · PI GUO, HONGYAN · 2023 to 2024
$402kNCI NIH HHS P30 CA006927NCI NIH HHS R01 CA168621NCI NIH HHS R21 CA303392NIAID NIH HHS HHSN272201400006CNIAID NIH HHS R01 AI121832NIAID NIH HHS R01 AI135025NIAID NIH HHS R01 AI144400NIAID NIH HHS R01 AI171568NIAID NIH HHS R21 AI175590NIGMS NIH HHS P20 GM134974
Abstract
Herpes simplex virus 1 (HSV-1) and influenza A viruses (IAV) induce Z-form-nucleic-acid-binding protein 1 (ZBP1)-initiated cell death
Indexed as
Herpes SimplexHerpesvirus 1, HumanHost-Pathogen InteractionsInfluenza A virusRNA-Binding ProteinsAnimalsCleavage And Polyadenylation Specificity FactorHumansImmediate-Early ProteinsInfluenza, HumanLigandsRNA, MessengerViral Nonstructural ProteinsCleavage And Polyadenylation Specificity FactorICP27 protein, human herpesvirus 1Immediate-Early ProteinsINS1 protein, influenza virusLigandsRNA-Binding ProteinsRNA, MessengerViral Nonstructural ProteinsZBP1 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.