Observational studyCritical care explorations2025
Physiological Signal Entropy in Pediatric Traumatic Brain Injury: Looking Beyond the Obvious: A STARSHIP Study.
Observational study in Critical care explorations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Multiscale Entropy Reveals Reduced Airflow Complexity in Chronic Obstructive Pulmonary Disease: Associations with Spirometry and Diagnostic Utility.Annals of biomedical engineering · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
objectivesMultimodality monitoring based prognostication in pediatric traumatic brain injury (TBI) relies heavily on the evaluation of instantaneous and easily interpretable monitoring values. Entropy quantifies the level of disorder within a system reflecting overall activity of sensitive closed-loop feedback homeostatic mechanisms. Multiscale entropy (MSE) assesses entropy across different time scales to examine various physiologic systems and processes that operate across different time scales. The current understanding of MSE suggests that low entropy reflects increased rigidity of the various homeostatic control systems, reflecting underperformance of mechanisms such as cerebral autoregulation. This hypothesis-generating retrospective study explores the value of MSE for prognostication after pediatric TBI.
designRetrospective analysis of data from an observational multicenter database.
settingTen PICUs across the United Kingdom. PATIENTS: One hundred thirty-five children with severe pediatric TBI receiving invasive neuromonitoring between 2018 and 2022.
interventionsNone. MEASUREMENTS AND MAIN
resultsMSE was calculated based on 10-second time trends of different biosignals (incl. blood pressure, heart rate, intracranial pressure [ICP]). MSE metrics were assessed using univariable and multivariable (logistic regression with backward stepwise elimination and sliding dichotomy) methods. Last, correlation coefficients between MSE and clinical or monitoring metrics were assessed. Decreased MSE of physiologic biosignals were associated with worse outcomes and remained associated with outcomes when added to multivariable analyses. Within multivariable logistic regression analyses (covariates: Injury Severity Score [ISS], Rotterdam score, ICP, pressure reactivity index [PRx]), the resulting odds ratios (ORs) were: MSE arterial blood pressure (abp: OR, 0.83; p = 0.014), MSE cerebral perfusion pressure (cpp: OR, 0.86; p = 0.024), and MSE icp (OR, 0.87; p = 0.029). MSE displayed weak associations with clinical parameters reflecting higher TBI severity (i.e., ISS, Abbreviated Injury Scale, Glasgow Coma Scale, etc.) but moderate correlations with PRx (correlation coefficients: MSE abp, -0.47; MSE cpp, -0.55) and ICP (MSE abp, -0.3).
conclusionsBiosignal complexity is a promising tool for improving individualized prognostication after pediatric TBI. Our results further underpin the association between MSE and the function of physiologic autoregulatory mechanisms.
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