Evidence map›Paper›PMID 41082480›Full record

Trial reportAnnals of surgery2025

Long-term Follow-up After Hypothermic Oxygenated Machine Perfusion in DCD Liver Transplantation: Results of a Randomized Controlled Multicenter Trial (DHOPE-DCD).

Rianne van Rijn, Chikako Endo, Efrayim H Küçükerbil, Hans Blokzijl, Joris Blondeel, Miriam Cortes Cerisuelo, Minneke J Coenraad, Sarwa Darwish Murad, Michail Doukas, Hasan Eker and 9 more

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Annals of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02584283 (A Multicenter Randomized Controlled Trial to Compare the Efficacy of End-ischemic Dual Hypothermic Oxygenated Perfusion With Standard Static Cold Storage of Liver Grafts Donated After Circulatory Death in Preventing Biliary Complications), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02584283 phase3completednot on this map

A Multicenter Randomized Controlled Trial to Compare the Efficacy of End-ischemic Dual Hypothermic Oxygenated Perfusion With Standard Static Cold Storage of Liver Grafts Donated After Circulatory Death in Preventing Biliary Complications

TypeinterventionalSponsorRobert J. PorteRan2016 to 2020Enrolled157ConditionsLiver Failure, End Stage Liver Disease, Biliary Tract DiseasesArmsDual hypothermic oxygenated perfusion, Liver Assist®, Perfusion fluid, Glutathione
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Review
  6. Abdominal Organ Transplantation: Noteworthy Literature in 2025.Seminars in cardiothoracic and vascular anesthesia · 2026
    Review
  7. Article
  8. Article
  9. Evaluation of the Prevalence of Occult Fibrin in Donor Organs, Its Origins, and Consequences: Insights From the COPE Studies.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Rianne van RijnDepartment of Surgery, Section Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Chikako EndoDepartment of Surgery, Section Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Efrayim H KüçükerbilErasmus MC Transplant Institute, Department of Surgery, Division of HPB and Transplant Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Hans BlokzijlDepartment of Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Joris BlondeelAbdominal Transplantation, KU Leuven, University Hospitals Leuven, Leuven, Belgium.
Miriam Cortes CerisueloInstitute of Liver Studies, Kings College Hospital NHS Foundation Trust, London, UK.
Minneke J CoenraadDepartment of Gastroenterology and Hepatology, Transplant Center, Leiden University Medical Center, Leiden, The Netherlands.
Sarwa Darwish MuradDepartment of Gastroenterology and Hepatology, Erasmus Transplant Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-2804-1165
Michail DoukasDepartment of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Hasan EkerDepartment of Transplant Surgery, Ghent University Hospital, Ghent, Belgium.
Robbert J de HaasDepartment of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Volkert A L HuurmanDepartment of Surgery, Transplant Center, Leiden University Medical Center, Leiden, The Netherlands.
Vincent E de MeijerDepartment of Surgery, Section Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0002-7900-5917
Diethard MonbaliuAbdominal Transplantation, KU Leuven, University Hospitals Leuven, Leuven, Belgium.
Ivo J SchurinkErasmus MC Transplant Institute, Department of Surgery, Division of HPB and Transplant Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Jules J G SlangenDepartment of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Wojciech G PolakErasmus MC Transplant Institute, Department of Surgery, Division of HPB and Transplant Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Jeroen de JongeErasmus MC Transplant Institute, Department of Surgery, Division of HPB and Transplant Surgery, Erasmus University Medical Center, Rotterdam, The Netherlands.
Robert J PorteDepartment of Surgery, Section Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0003-0538-734

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimTransplantation of livers from donation after circulatory death (DCD) donors is associated with an increased risk of nonanastomotic biliary strictures (NAS). Dual hypothermic oxygenated machine perfusion (DHOPE) of donor livers before transplantation has been shown to reduce the incidence of symptomatic NAS and acute cellular rejection (ACR) within 6 months, but long-term results are unknown. The aim of this study was to assess the 5-year incidence of NAS and ACR in the DHOPE-DCD Trial (ClinicalTrials.gov number NCT02584283).

methodsBetween January 2016 and July 2019 recipients of DCD livers in 6 European centers were randomly assigned to receive that liver either after DHOPE (machine perfusion group) or after conventional static cold storage (control group). Primary endpoint was the incidence of NAS at 5-year follow-up. Secondary endpoints included ACR, graft, and patient survival.

resultsA total of 78 patients were included in the machine perfusion group and 78 patients in the control group. After 5 years of follow-up, the incidence of NAS was significantly lower in the machine perfusion group, compared with control group: 14% versus 26% (hazard ratio: 0.47, 95% CI: 0.23-0.99; P=0.048). In patients with immune-mediated disease, who are at increased risk of ACR, the rate of ACR was significantly lower in the machine perfusion group: 0% versus 32% (P=0.036).

conclusionsThe short-term benefits of DHOPE in DCD liver transplantation persist up to 5-year post-transplant, with significant reductions in incidence of NAS, and ACR in high-risk patients, compared with conventional static cold storage.

Indexed as

Hypothermia, InducedLiver TransplantationOrgan PreservationPerfusionAdultConstriction, PathologicFemaleFollow-Up StudiesGraft RejectionGraft SurvivalHumansIncidenceMaleMiddle AgedTime Factorsacute rejectiondonation after circulatory deathhypothermic machine perfusionliver transplantationlong-term follow-upnonanastomotic biliary stricturesstatic cold storage

Identifiers

PMID41082480
PMCPMC12513034

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.