Evidence map›Paper›PMID 41082348›Full record

ArticleAnnals of medicine2025

Higher cardiometabolic index elevates the risk of hyperuricemia in the elderly: findings from the China health and retirement longitudinal study.

Lei Zhong, Da Li, Feifei Xu, Yi Wu, Yanyuan Zhang

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Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Lei ZhongDepartment of Urology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.ORCID 0009-0007-9254-5612
Da LiDepartment of General Internal Medicine, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China.ORCID 0009-0004-0451-7469
Feifei XuDepartment of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, P.R. China.ORCID 0000-0001-8974-9867
Yi WuDepartment of Urology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.ORCID 0009-0006-7758-9601
Yanyuan ZhangDepartment of Anesthesiology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Cheng Du, China.ORCID 0009-0002-3195-263X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHyperuricemia (HUA) is the direct cause of gouty arthritis. The association between cardiometabolic index (CMI) and hyperuricemia remains unclear. This study aimed to examine this association in the middle-aged and elderly Chinese for preventing gouty arthritis at early stage.

methodThis study was based on China Health and Retirement Longitudinal Study (CHARLS, survey 2011 and 2015). Four logistic regression models were established. Sensitive analysis including propensity score matching (PSM) and inverse probability of treatment weighting (IPTW), etc. were applied to identify the robustness of the models. Restricted cubic spline (RCS) was adopted to further explore the non-linear relationship between the CMI and hyperuricemia. Moreover, as the HUA was caused by the abnormal elevation of serum uric acid (SUA), Cross-lagged panel model (CLPM) was used to investigate the causal relationship between CMI and SUA. Mediation analysis was used to explore the possible mechanisms about the interference of CMI to HUA.

resultsA total of 5,653 participants were enrolled in this study. A positive association between CMI and hyperuricemia was found in both the cross-sectional and longitudinal analysis. In the four logistic regression models of longitudinal analysis, the ORs were 2.09(1.73,2.54), 2.20(1.81,2.68), 2.09(1.71,2.56) and 1.93(1.57,2.36), respectively. Results maintained consistent in the sensitive analysis including PSM and IPTW. Importantly, it still holds in the participants with normal body mass index. Additionally, a non-linear relationship was revealed

conclusionElevated CMI is an independent risk factor for hyperuricemia, and associated with the increasing SUA levels in a temporal sequence manner, effects potentially mediated in part by inflammation.

Indexed as

Arthritis, GoutyCardiometabolic Risk FactorsHyperuricemiaAgedChinaCross-Sectional StudiesFemaleHumansLogistic ModelsLongitudinal StudiesMaleMiddle AgedPropensity ScoreRisk FactorsUric AcidUric Acidcardiometabolic indexgouty arthritisHyperuricemiaserum uric acidthe China Health and Retirement Longitudinal Study

Identifiers

PMID41082348
PMCPMC12519585

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