ReviewEnvironmental science & technology2025
Disinfection Byproducts Confirmed over 50 Years: Systematic Curation, Modes of Toxic Action, and Toxicogenomics.
Review in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Controls of disinfection byproducts and biotoxicity in chlorinated post-denitrifying effluents: Optimization of the carbon-to-nitrogen ratio and hydraulic retention time.Eco-Environment & Health · 2026Article
- Long-Term Adverse Effects of Chlorinated Saline Primary Sewage Effluent and Halo-Nitrophenolic Disinfection Byproducts on a Marine Polychaete.Environment & health (Washington, D.C.) · 2026Article
- Advancing the Discovery of Emerging Contaminants: A Leap in Technology and Data.Environmental science & technology · 2026Review
- Metabolic Disruption and Steatosis Induced by Drinking Water Disinfection Byproducts in HepG2 and HUH7 Cells.Toxics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Research on water disinfection byproducts (DBPs) over the past 50 years has unveiled more than 700 DBPs, many of which pose unrecognized risks to human health. Despite significant progress, systematic integration of the chemical curation of the confirmed DBPs with emerging toxicological paradigms is missing. This review systematically curates 716 confirmed DBPs reported from 1974 to 2024, offering a comprehensive resource to support risk identification and prioritization. We introduce a multiple classification framework based on molecular scaffolds, functional groups, and halogenation patterns, enabling researchers to map structural diversity to toxicological profiles. The modes of action applied in DBP research outlined here include nonspecific baseline toxicity, receptor- or enzyme-specific interactions, and reactive mechanisms such as oxidative stress and genotoxicity. Furthermore, we provide a system-level toxicogenomic view of DBP-induced toxicity, which has progressed from static single- and multiomics approaches to emerging time-resolved omics. These approaches reveal DBP-induced perturbations: the genome defines susceptibility, the transcriptome reflects expression levels, the proteome indicates functional execution, and the metabolome captures phenotypic outcomes. This review underscores critical knowledge gaps while charting future directions for DBP risk assessment and regulation and supports global efforts toward clean and safe drinking water.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.