ArticleAnnals of Indian Academy of Neurology2025
Self-Limited Epilepsy with Centrotemporal Spikes in Younger Ages: Worse but Real!
Article in Annals of Indian Academy of Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
BACKGROUND AND
objectiveTo compare the clinical features and consequences of self-limited epilepsy with centrotemporal spikes (SeLECTS) between two age groups by the consideration of a pediatric cohort.
methodsPatient data and follow-up observations of children with SeLECTS were documented between 2012 and 2023. Clinical profiles, electrocephalogram (EEG) patterns, and treatment details of the children diagnosed with SeLECTS were retrospectively examined and analyzed in two separate groups based on age at diagnosis.
resultsA group of 198 patients with SeLECTS was included. The study group was divided into two subgroups as the group under age 5 (n = 54) and the group over age 5 (n = 144). The number of antiepileptics needed for seizure control ( P = 0.041) and the need for more than one antiepileptic ( P = 0.02) were found to be higher, with statistical significance, in the group younger than 5 years old. Moreover, the duration of control of seizures ( P < 0.001) and recovery of EEG was longer ( P < 0.001) in the group younger than 5 years. Electrical status epilepticus in slow-wave sleep emerged in four patients, and findings revealed that all of these patients were in the group over the age of 5.
conclusionsSeLECTS patients diagnosed under the age of 5 experience a longer duration to achieve seizure control and EEG normalization. Additionally, these patients often require a greater number of antiepileptic medications for effective seizure management.
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