Evidence map›Paper›PMID 41082177›Full record

Trial reportAnnals of the New York Academy of Sciences2025

Training-Induced Neural Enhancement of Novel Song Learning in Chronic Aphasia: EEG Study.

Emma Oksanen, Emmi Pentikäinen, Anni Pitkäniemi, Sini-Tuuli Siponkoski, Sari Laitinen, Essi-Reetta Särkämö, Aleksi J Sihvonen, Tommi Makkonen, Jaakko Kauramäki, Teppo Särkämö

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Annals of the New York Academy of Sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emma OksanenCognitive Brain Research Unit & Centre of Excellence in Music, Mind, Body and Brain, Department of Psychology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Emmi PentikäinenCognitive Brain Research Unit & Centre of Excellence in Music, Mind, Body and Brain, Department of Psychology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Anni PitkäniemiCognitive Brain Research Unit & Centre of Excellence in Music, Mind, Body and Brain, Department of Psychology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Sini-Tuuli SiponkoskiCognitive Brain Research Unit & Centre of Excellence in Music, Mind, Body and Brain, Department of Psychology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Sari LaitinenEspoo Hospital, Espoo, Finland.
Essi-Reetta SärkämöPrivate Choir Conductor, Vantaa, Finland.
Aleksi J SihvonenCognitive Brain Research Unit & Centre of Excellence in Music, Mind, Body and Brain, Department of Psychology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-4501-7338
Tommi MakkonenCognitive Brain Research Unit & Centre of Excellence in Music, Mind, Body and Brain, Department of Psychology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Jaakko KauramäkiCognitive Brain Research Unit & Centre of Excellence in Music, Mind, Body and Brain, Department of Psychology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
Teppo SärkämöCognitive Brain Research Unit & Centre of Excellence in Music, Mind, Body and Brain, Department of Psychology, Faculty of Medicine, University of Helsinki, Helsinki, Finland.ORCID 0000-0002-1470-4530

Funding

201729.32299044, 306625, 327996, 346211803466European Research CouncilFundació la Marató de TV3Research Council of Finland
6 · The paper itself

Abstract

While singing-based rehabilitation can aid language recovery in aphasia, little is currently known about how persons with aphasia (PWA) are able to learn new songs. Using data from a previous crossover randomized controlled trial, this electroencephalography (EEG) study explored the effects of a 16-week multicomponent singing intervention on neural learning of novel song material in 24 PWA, reflected by the mismatch negativity (MMN) response, and its correlation with changes in communication and verbal learning. In pre- and postintervention EEG measurements, PWA participants listened to modulated versions of two novel songs (trained vs. untrained during intervention) using a passive oddball design with pitch, phoneme, and duration deviants embedded in the melody. Significant changes in MMN were observed for the trained versus untrained songs from pre- to postintervention for phoneme and frequency deviants. Especially for phoneme deviants, the MMN amplitude in left frontotemporal areas decreased for the trained song but increased for the untrained song. These findings suggest that singing intervention can induce neural learning of song material in PWA.

Indexed as

AphasiaElectroencephalographyLearningMusicSingingAdultAgedChronic DiseaseFemaleHumansMaleMiddle AgedMusic Therapyaphasiaauditory processingelectroencephalographylearningmismatch negativityMMNsinging

Identifiers

PMID41082177
PMCPMC12645264

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.