Evidence map›Paper›PMID 41082171›Full record

ArticleEuropean geriatric medicine2026

Muscle strengthening activities: cross-sectional associations with skeletal muscle outcomes in adults aged 50-64 and 65 years and above.

Konstantinos Prokopidis, Stefano Cacciatore, Paolo Piaggi, Davide Liborio Vetrano, Mathias Schlögl

Abstract read
In one paragraph

Article in European geriatric medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Konstantinos ProkopidisDepartment of Musculoskeletal Ageing and Science, Institute of Life Course and Medical Sciences, University of Liverpool, 6 West Derby St, Liverpool, L7 8TX, UK. k.prokopidis@liverpool.ac.uk.ORCID 0000-0002-6264-9388
Stefano CacciatoreDepartment of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, L.go F. Vito 1, 00168, Rome, Italy.
Paolo PiaggiDepartment of Information Engineering, University of Pisa, Pisa, Italy.
Davide Liborio VetranoDepartment of Neurobiology, Aging Research Center, Care Sciences and Society, Karolinska Institutet and Stockholm University, Solna, Sweden.
Mathias SchlöglDepartment for Geriatric Medicine, Clinic Barmelweid, Erlinsbach, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo examine the association of muscle strengthening activities with knee extension strength, gait speed, and skeletal muscle index in adultsaged 50-64 and ≥65 years.

findingsMuscle strengthening activities are linked to better gait speed, knee extension strength, and skeletal muscle index mainly in middle-aged adults (50-64 years), with weaker or no associations in older adults except for higher activity frequency (≥8 sessions/month), benefi tingstrength in those ≥65 years. MESSAGE: Muscle strengthening activities are linked to better physical function and muscle health in middle-aged compared to older adults,although frequency may be a confounding parameter.

backgroundThis study examined the association of muscle strengthening activities (MSA) with knee extension strength (KES) and gait speed (GS) (n = 2169), and skeletal muscle index (SMI; n = 765) in adults aged 50-64 and ≥ 65 years.

methodsData were drawn from the National Health and Nutrition Examination Survey 1999-2018 cycles. MSA were self-reported based on engagement with weightlifting, push-ups, or sit-ups. MSA frequency was categorized as ≥ 8 or < 8 sessions/month. Linear and logistic regressions were performed, adjusting for demographic and clinical covariates.

resultsMSA were associated with improved GS and KES across adults aged 50-64 years in fully adjusted models (GS: β = -0.24, 95% CI - 0.42 to - 0.07; KES: β = 31.7, 95% CI 18.9 to 44.5) but not in those ≥ 65 years (GS: p = 0.07; KES: p = 0.11). For SMI, a significant positive association emerged only in the 50-64-year old group after adjustments (β = 0.18, 95% CI 0.03 to 0.34; ≥ 65 years → p = 0.53). Age interaction (≥ 65 vs. 50-64 years) showed significant MSA associations with GS and KES, though SMI results were inconsistent. Finally, higher MSA frequency for ≥ 65 versus 50-64 years was linked to higher KES (β = 22.0, p = 0.03), but not GS (p = 0.05) or SMI (p = 0.64).

conclusionsMSA are associated with higher KES and GS in middle-aged, but not in older adults. Higher MSA frequency is linked to increased KES in older adults.

Indexed as

Muscle, SkeletalMuscle StrengthResistance TrainingWalking SpeedAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedNutrition SurveysGait speedMuscle massMuscle strengthResistance trainingSarcopenia

Identifiers

PMID41082171
PMCPMC12946235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.