ReviewCurrent osteoporosis reports2025
The Periosteum in Health and Disease.
Review in Current osteoporosis reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Stromal Defense Against Cancer: An Unprecedented Mechanism Limiting Cancer Invasion Into the Bone.Cancer science · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThe periosteum has long been recognized as being essential for bone growth and repair. More recently, its involvement has been observed in a range of pathological conditions, including cancer progression and invasion, premature closure of the growth plate, bone pain, pseudarthrosis, and craniosynostosis. Given that the periosteal reaction often serves as an early indicator of skeletal abnormalities, the periosteum likely plays a pivotal role at the interface of bone health and disease. In this review, recent advances in our understanding of periosteal biology are highlighted. RECENT
findingsRecent studies employing lineage tracing and genetic loss-of-function approaches have highlighted the critical role of periosteal stem cells and their progenies, as well as periosteum/perichondrium-derived factors, in both bone physiology and pathology. Crosstalk between the periosteum/perichondrium and the growth plate controls skeletal growth, and complex multicellular interactions in the periosteum underlies the pathogenesis of pseudarthrosis and craniosynostosis. The protective role of the periosteum against cancer progression has garnered attention, expanding our understanding of periosteum function. It is now evident that the periosteum is a crucial skeletal element that is key for maintaining vertebrate homeostasis. Future research into the cellular communication in the periosteum, as well as its interactions with other skeletal elements and extra-skeletal systems, will be key to develop novel therapeutic strategies for skeletal diseases.
Indexed as
Identifiers
41082083What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.