Evidence map›Paper›PMID 41082081›Full record

ArticleInflammopharmacology2025

Unveiling the antioxidant and anti-inflammatory potentials of Gomphostigma virgatum and analyzing its phytochemical profile.

Emmanuel Mfotie Njoya, Gaetan T Tabakam, Chika I Chukwuma, Tshepiso J Makhafola

Abstract read
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In one paragraph

Article in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Emmanuel Mfotie NjoyaCentre for Quality of Health and Living, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein, 9301, Free State, South Africa. mfotiefr@yahoo.fr.ORCID http://orcid.org/0000-0003-1163-7202
Gaetan T TabakamCentre for Quality of Health and Living, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein, 9301, Free State, South Africa.
Chika I ChukwumaCentre for Quality of Health and Living, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein, 9301, Free State, South Africa.
Tshepiso J MakhafolaCentre for Quality of Health and Living, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein, 9301, Free State, South Africa. jmakhafola@cut.ac.za.ORCID http://orcid.org/0000-0002-8335-9611

Funding

Central University of Technology RES. 10/22/04National Research Foundation (ZA) CSRP200429517876
6 · The paper itself

Abstract

The potential of phytoconstituents from Gomphostigma virgatum to modulate molecular markers of oxidative stress and chronic inflammation, which are two major contributors to the development of numerous diseases, is still unknown. The present study aimed to investigate the antioxidant and anti-inflammatory potentials of G. virgatum in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, as well as to isolate bioactive ingredients via a silica-gel column fractionation. Further, a quantitative estimation of phenolics and flavonoids was carried out using colorimetric methods, and liquid chromatography-mass spectrometry was utilized to identify potential bioactive compounds. The results showed that G. virgatum hydroethanolic leaf extract (GVHLE) and its isolated fraction F

Indexed as

Anti-Inflammatory AgentsAntioxidantsPhytochemicalsPlant ExtractsAnimalsFlavonoidsInflammationLipopolysaccharidesMacrophagesMiceNitric OxideOxidative StressPhenolsPlant LeavesRAW 264.7 CellsReactive Oxygen SpeciesAnti-Inflammatory AgentsAntioxidantsFlavonoidsLipopolysaccharidesNitric OxidePhenolsPhytochemicalsPlant ExtractsReactive Oxygen SpeciesActeosideFree radicalsGomphostigma virgatumInflammatory mediatorsOxidative stress

Identifiers

PMID41082081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.