Evidence map›Paper›PMID 41082063›Full record

ArticleTropical animal health and production2025

Expression of LGALS3 and XPNPEP2 genes and their association with growth traits in sheep.

Guoxing Jia, Weimin Wang, Huibing Tian, Xiaojuan Wang, Yukun Zhang, Yuan Zhao, Lijuan He, Zongwu Ma, Xioabing Yang, Dan Xu and 15 more

Abstract read
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Article in Tropical animal health and production, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Guoxing JiaCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, 730070, China.
Weimin WangThe State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu, 730020, China.
Huibing TianThe State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu, 730020, China.
Xiaojuan WangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, 730070, China.
Yukun ZhangThe State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu, 730020, China.
Yuan ZhaoThe State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu, 730020, China.
Lijuan HeCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, 730070, China.
Zongwu MaThe State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu, 730020, China.
Xioabing YangThe State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu, 730020, China.
Dan XuThe State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu, 730020, China.
Kunchao HanThe State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu, 730020, China.
Peiliang CaoCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, 730070, China.
Mengru PuThe State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu, 730020, China.
Lingting LiCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, 730070, China.
Dewen KongCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, 730070, China.
Jian ZhangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, 730070, China.
Hongjian LiCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, 730070, China.
Qi ZhangThe State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu, 730020, China.
Chenqi YanThe State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu, 730020, China.
Ziyue XiaoThe State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu, 730020, China.
Lianjun FenThe State Key Laboratory of Grassland Agro-Ecosystems, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, Gansu, 730020, China.
Bo MaCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, 730070, China.
Xinji WangMinqin County Animal Husbandry and Veterinary Station, Minqin, Gansu, 733399, China.
Zhaocai ZhangGansu Yang Ruxiang Agriculture Co., Ltd., Gulang, Gansu, 733100, China.
Xiaoxue ZhangCollege of Animal Science and Technology, Gansu Agricultural University, Lanzhou, Gansu, 730070, China. zhangxx@gsau.edu.cn.ORCID http://orcid.org/0000-0002-3289-5393

Funding

Financial Special Program of the National Agricultural Science and Technology Park in Wuwei, Gansu WNKY2024QY005Gansu Provincial Major Science and Technology Program 22ZD6NC069The National Key Research and Development Program of China (2022YFD1302000 and 2023YFF1001000Wuwei Municipal Science and Technology Program WW23A03ZDQ001
6 · The paper itself

Abstract

Growth traits are critical economic factors in sheep breeding and are influenced by various elements. This study aims to identify the expression levels of the LGALS3 and XPNPEP2 genes in Hu sheep, as well as to explore the association between single nucleotide polymorphisms (SNPs) and growth traits using qRT-PCR, DNA sequencing, and AQP™ typing technology, thereby providing a theoretical basis for marker-assisted selection in sheep breeding. The results showed that both LGALS3 and XPNPEP2 genes had intronic mutations: g.65,688,711 T > C and g.113,699,247 C > T. Both genes were expressed in all ten tissues analyzed, with LGALS3 being most highly expressed in spleen tissue and XPNPEP2 being most highly expressed in kidney tissue. Association analyses revealed that the LGALS3 g.65,688,711 T > C and XPNPEP2 g.113,699,247 C > T polymorphisms were significantly associated with growth traits. Furthermore, analysis of different genotype combinations indicated that various combinations of LGALS3 and XPNPEP2 genotypes displayed significant differences in the growth traits of Hu sheep across different growth stages (P < 0.05). Thus, the polymorphisms of the LGALS3 and XPNPEP2 genes may serve as potential markers for growth traits in Hu sheep.

Indexed as

Galectin 3Sheep, DomesticAnimalsBreedingGenotypePolymorphism, Single NucleotideSequence Analysis, DNASheepGalectin 3Expression profilesGrowth traitsHu sheepLGALS3SNPXPNPEP2

Identifiers

PMID41082063

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.