Evidence map›Paper›PMID 41082056›Full record

ReviewMolecular biology reports2025

Emerging roles of Midnolin in Cancer, Parkinson's Disease, and Metabolic dysfunction.

Madhur Kalyan, Pankaj Kumar Singh, Arpana Verma

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Madhur KalyanDepartment of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India. mdhrkalyan@gmail.com.
Pankaj Kumar SinghDepartment of Biochemistry, All India Institute of Medical Sciences, Vijaypur, Jammu, Jammu and Kashmir, India.
Arpana VermaDepartment of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Midnolin has emerged as a versatile protein involved in gene regulation, metabolism and disease. It controls Early Response Genes by promoting their ubiquitin-independent proteasomal degradation. It also affects glucose metabolism by interacting with glucokinase in pancreatic beta cells. Recent studies have highlighted the significant role of Midnolin in various human diseases, including non-alcoholic fatty liver disease, Parkinson's disease, and several malignancies such as liver cancer, breast cancer, gastric cancer, multiple myeloma and B-cell leukemias and lymphomas. Moreover, it has also been linked to lipid metabolism, mitochondrial function and tumor growth. However, its exact role is still not fully understood. This review summarizes current knowledge about Midnolin functions and highlights its potential target for future research in health and disease.

Indexed as

Metabolic DiseasesNeoplasmsParkinson DiseaseAnimalsHumansLipid MetabolismMitochondriaCancerMidnolinNon-Alcoholic fatty liver diseaseParkinson’s disease

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.