ArticleInternational ophthalmology2025
Diagnostic analysis of angle-closure using the iris-trabecular contact (ITC) index of CASIA2 swept source anterior segment optical coherence tomography.
Article in International ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Pathogenesis of Neovascular Glaucoma in Diabetic Retinopathy: A Review.Journal of ophthalmology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the diagnostic performance of the iris-trabecular contact (ITC) index measured with the CASIA2 anterior segment optical coherence tomography (AS-OCT) device, in the determination of angle-closure compared with gonioscopy, and to study the degree of agreement between both methods.
methodsA total of 135 eyes (76 open-angle subjects and 59 patients with gonioscopic angle-closure) underwent ITC analysis (the percentage of angle-closure over the 360° circumference) with the CASIA2 AS-OCT device. Dynamic gonioscopy was performed and angle-closure was defined as non-visibility of the trabecular meshwork in ≥ 2 quadrants. The area under the curve (AUC) of the receiver operating characteristic curve for the ITC index was calculated. Sensitivity, specificity, and positive and negative predictive values were determined for various ITC cut-off points. The degree of agreement between the ITC index and gonioscopy was analyzed.
resultsThe mean ITC index was 3.5 ± 7.8% for eyes with open angle and 34.1 ± 22.2% for gonioscopic angle-closure cases (p < 0.001). The AUC was 0.88 for an ITC cut-off point ≥ 20%, with sensitivity and specificity values of 93.2% and 83.5%, respectively. The overall agreement between CASIA2 and gonioscopy was 85.2%, with false positive and negative rates of 7.4% each. The ITC index showed a direct strong correlation with the number of quadrants gonioscopically defined as angle-closure (r = 0.68).
conclusionsCASIA2 showed excellent diagnostic performance of the ITC index for the assessment of angle-closure and moderate agreement with gold standard gonioscopy. This promising approach provides precise information on the actual situation of the anterior chamber angle.
Indexed as
Identifiers
41081976What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.