ArticleNeurosurgical review2025
Association between perivascular spaces, DTI-derived Indices, and choroid plexus with ventriculomegaly and white matter hyperintensity in idiopathic normal pressure hydrocephalus.
Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- The glymphatic system and Parkinson's disease: a narrative review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Review
- MRI-based cerebrospinal fluid volumetric indices for predicting tap test response in idiopathic normal pressure hydrocephalus.Radiological physics and technology · 2026Observational
- DTI-ALPS Is Associated with Temporolimbic Amyloid but Not Plasma p-Tau181 Across the Alzheimer's Disease Continuum.Research square · 2026Article
- Hippocampal T1WI radiomics- and clinical feature-based models for predicting early mild cognitive impairment in secondary hydrocephalus.Frontiers in aging neuroscience · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
This study aimed to investigate perivascular spaces (PVS), Diffusion tensor imaging (DTI)-derived indices, and choroid plexus in patients with iNPH and to assess potential associations between these MRI indices and ventriculomegaly and WMH.This single-center, cross-sectional retrospective study included healthy controls (HCs) and patients with iNPH who underwent 3.0T MRI measurements including MRI-visible PVS volume fraction (PVSVF), fractional volume of free water in white matter (FW-WM), the diffusion tensor image analysis along the perivascular space (DTI-ALPS), and choroid plexus volume fraction (CPVF). Among them, FW-WM and DTI-ALPS are DTI-derived indices. MRI measurements were compared and correlated with ventricular parameters and WMH in both groups using general linear univariate model and partial Spearman rank correlation tests.Fifty-six patients with iNPH (71.5 ± 7.7 years; 34 males) and 47 HCs (69.1 ± 6.3 years; 26 males) were analyzed. Patients with iNPH had significantly higher PVSVF, FW-WM, and CPVF, and a lower DTI-ALPS index than HCs (all p < 0.001). Lower DTI-ALPS (iNPH group: r = -0.625; HCs group r = -0.629; all p corrected for false discovery rate (FDR) < 0.001) and higher CPVF (iNPH group: r = 0.462, pFDR < 0.001; HCs group r = 0.444, pFDR = 0.027) were correlated with a larger relative ventricular volume. Lower DTI-ALPS (r = 0.390, pFDR = 0.030) and higher CPVF (r = -0.385, pFDR = 0.023) correlated with lower relative extra-ventricular CSF volume only in the iNPH group.iNPH exhibited higher PVS, FW-WM, and CPVS and lower DTI-ALPS. Lower DTI-ALPS and higher CPVS may play important roles in ventriculomegaly and alterations in CSF distribution in iNPH.
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