ArticleBiogerontology2025
Genetically predicted causal links between gut microbiota and biological aging phenotypes in age-related macular degeneration.
Article in Biogerontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Gut Microbiota Signatures and Potential Mediators in the Trajectory of Age-related Macular Degeneration: A Phased Atlas by Genetic Inference.International journal of medical sciences · 2026Article
- Causal relationships between cerebrospinal fluid metabolites, immune cell traits, and head and neck cancers.Discover oncology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Current knowledge regarding the role of gut microbiota (GM) dysbiosis and biological aging in the pathogenesis of age-related macular degeneration (AMD) remains limited. This study aims to explore the causal relationships among these factors in AMD development. Utilizing two-sample bidirectional mendelian randomization (MR), we analyzed genome-wide association study (GWAS) data from 105,248 individuals, including 14,034 early AMD cases, to assess causality between AMD, GM taxa, and biological aging phenotypes such as epigenetic clocks, telomere length, mitochondrial DNA copy number, immune cell traits, and inflammatory proteins. Multivariable MR (MVMR) was employed to evaluate mediation pathways, complemented by sensitivity analyses to ensure robustness. We identified 8 causal GM taxa (including one phylum, one class, one order, one family, and four species) along with 8 GM functional pathways. Additionally, 78 immune cell traits, 3 circulating inflammatory proteins, and DNA methylation PhenoAge acceleration were identified as causal biological aging phenotypes linked to AMD. Mediation analysis revealed three pathways connecting GM functional pathways, immune cell traits, and AMD. Reverse MR analysis highlighted the modifying effects of AMD on GM and other aging phenotypes. This study represents a pioneering effort to identify causal GM taxa associated with the onset of AMD and to unravel potential mechanisms from the perspective of biological aging, providing genetic insights into the connections among gut microbiota, immune cell traits, and AMD.
Indexed as
Identifiers
41081949What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.