Evidence map›Paper›PMID 41081860›Full record

ArticleSurgery today2026

Frey procedure for chronic pancreatitis improves bile duct stricture.

Hideaki Sato, Masaharu Ishida, Naohiro Hirano, Shuichiro Hayashi, Shingo Yoshimachi, Akiko Kusaka, Mitsuhiro Shimura, Shuichi Aoki, Masahiro Iseki, Daisuke Douchi and 7 more

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Hideaki SatoDepartment of Surgery, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Masaharu IshidaDepartment of Surgery, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan. masaharu.ishida.d3@tohoku.ac.jp.
Naohiro HiranoDepartment of Surgery, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Shuichiro HayashiDepartment of Surgery, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Shingo YoshimachiDepartment of Surgery, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Akiko KusakaDepartment of Surgery, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Mitsuhiro ShimuraDepartment of Surgery, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Shuichi AokiDepartment of Surgery, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Masahiro IsekiDepartment of Surgery, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Daisuke DouchiDepartment of Surgery, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Takayuki MiuraDepartment of Surgery, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Shimpei MaedaDepartment of Surgery, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Masamichi MizumaDepartment of Surgery, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Kiyoshi KumeDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Atsushi MasamuneDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Takashi KameiDepartment of Surgery, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.
Michiaki UnnoDepartment of Surgery, Tohoku University Graduate School of Medicine, Seiryomachi 1-1, Aobaku, Sendai, 980-8574, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposesChronic pancreatitis (CP), a progressive inflammatory disorder characterized by pancreatic fibrosis and degeneration, often leads to common bile duct (CBD) strictures. However, the optimal management of CBD strictures remains controversial.

methodsWe retrospectively analyzed 16 patients with CP and CBD strictures who underwent surgery at our institution between January 2007 and December 2024. Clinical characteristics, surgical outcomes, and impact of the Frey procedure on CBD stricture resolution were evaluated.

resultsAmong the 16 patients, 10 underwent biliary reconstruction and 6 underwent the Frey procedure alone. Postoperatively, CBD strictures improved in five of the six patients without biliary reconstruction (Frey alone), eliminating the need for a stent. Additionally, a long-term follow-up revealed that one patient who initially required a CBD stent experienced spontaneous improvement after the Frey procedure, suggesting its potential therapeutic effect on CBD strictures. A comparison between Frey procedure alone and biliary reconstruction cases revealed similar demographics; however, the Frey procedure alone significantly shortened operative time (p = 0.017).

conclusionThe Frey procedure improved CBD strictures in the majority of patients with CP by alleviating pancreatic head inflammation and fibrosis. However, biliary reconstruction may be necessary in some cases. Further studies are required to establish the optimal treatment strategies.

Indexed as

Common Bile DuctDigestive System Surgical ProceduresPancreatitis, ChronicPlastic Surgery ProceduresAdultAgedConstriction, PathologicFemaleFibrosisFollow-Up StudiesHumansMaleMiddle AgedOperative TimeRetrospective StudiesStentsBile duct strictureBiliary reconstructionCholedochojejunostomyChronic pancreatitisFrey procedure

Identifiers

PMID41081860
PMCPMC13013143

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.