ReviewArchives of microbiology2025
Molecular mechanisms of HCMV-driven vascular remodeling and its significance in cardiovascular diseases.
Review in Archives of microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Vascular remodeling, characterazied by dynamic structural and functional adaptations of blood vessels, is pivotal in the pathogenesis of various cardiovascular diseases. Its key processes include endothelial dysfunction, smooth muscle cell proliferation and migration, extracellular matrix metabolism dysregulation and abnormal angiogenesis. Human cytomegalovirus (HCMV), a prevalent herpesvirus, establishes latent infections in immunocompetent individuals and reactives in immunocompromised states. Accumulating evidence indicates that HCMV infection is closely linked to vascular remodeling: it disrupts the balance between vascular cell proliferation and apoptosis by regulating host cell cycle-related genes. Moreover, HCMV modulates G protein-coupled signaling through viral GPCR homologs or early proteins regulating host GPCR expression and downstream molecules, thereby affecting cytokine expression and signaling pathways. This review summarizes the elucidated mechanisms by which HCMV promotes vascular remodeling, aiming to provide directions for future studies on how this virus affects cell functions and vascular dynamics, and offer references for the treatment of related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.