ArticleJournal of agricultural and food chemistry2025
Maternal Aspartame Exposure Induces Neonatal Pulmonary Metabolic Dysregulation and Redox Imbalance: A Multiomics Investigation of Gut Microbiota-Host Interactions.
Article in Journal of agricultural and food chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Effects of Non-Nutritive Artificial Sweeteners on Gut Microbiota and Host Metabolism and Health-Related Outcomes: A Review.Nutrients · 2026Review
- HS-AssociatedMicroorganisms · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Redox imbalance during development may make offspring more vulnerable to long-term pulmonary issues. Maternal aspartame intake was investigated for its influence on neonatal lung redox biology. Using a multiomics approach (untargeted metabolomics, gut microbiota profiling, redox-inflammation markers), aspartame exposure (0.25 g/L in drinking water from gestational day 7 to postnatal day 21) was found to significantly alter neonatal pulmonary metabolic profiles, especially purine metabolism and the pentose phosphate pathway. MetOrigin analysis suggested a potential link between these metabolic changes and host-microbiota cometabolism. Elevated 8-hydroxy-2'-deoxyguanosine and malondialdehyde, along with decreased glutathione, suggested oxidative stress. These redox disturbances occurred with increased cleaved caspase-1 and interleukin-1β, consistent with inflammasome activation. Taken together, these integrated chemical and biological data propose a potential pathway by which early life aspartame exposures may disrupt redox-sensitive metabolic networks and inflammatory responses in the developing lung. These results emphasize the value of assessing artificial sweeteners when considering developmental redox homeostasis and immune-metabolic health.
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