Evidence map›Paper›PMID 41081533›Full record

ArticleProtein science : a publication of the Protein Society2025

Proton-linked effects on the axial coordination in ferric and ferrous horse heart cytochrome c.

Federico Sebastiani, Alessio Bocedi, Giovanna De Simone, Sara Notari, Giorgia Gambardella, Diego Sbardella, Giulietta Smulevich, Paolo Ascenzi, Massimo Coletta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Federico SebastianiDipartimento di Chimica "Ugo Schiff", DICUS, Università di Firenze, Sesto Fiorentino, Italy.
Alessio BocediDipartimento di Scienze e Tecnologie chimiche, Università di Roma Tor Vergata, Rome, Italy.
Giovanna De SimoneDipartimento di Scienze, Università Roma Tre, Rome, Italy.
Sara NotariDipartimento di Scienze e Tecnologie chimiche, Università di Roma Tor Vergata, Rome, Italy.
Giorgia GambardellaDipartimento di Scienze e Tecnologie chimiche, Università di Roma Tor Vergata, Rome, Italy.
Diego SbardellaIRCCS Fondazione Bietti, Rome, Italy.
Giulietta SmulevichDipartimento di Chimica "Ugo Schiff", DICUS, Università di Firenze, Sesto Fiorentino, Italy.
Paolo AscenziDipartimento di Scienze, Università Roma Tre, Rome, Italy.
Massimo ColettaIRCCS Fondazione Bietti, Rome, Italy.ORCID 0000-0002-5489-9467

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effect of pH (between pH 7.0 and 0.0) on the spectroscopic properties of ferric and ferrous derivatives of horse heart cytochrome c (hhcytc-Fe(III) and hhcytc-Fe(II), respectively) in 1.0M phosphate buffer is reported. This study further deepens the investigation of spectroscopic properties of a heme-protein to very low pH (i.e., pH ≈ 0) showing relevant pH-dependent variations of the heme surroundings, involving the heme-Fe atom coordination. For both hhcytc-Fe(III) and hhcytc-Fe(II) a severe weakening of the Fe-Met80 has been detected with a similar pK

Indexed as

Cytochromes cFerric CompoundsFerrous CompoundsMyocardiumProtonsAnimalsHemeHorsesHydrogen-Ion ConcentrationOxidation-ReductionCytochromes cFerric CompoundsFerrous CompoundsHemeProtonscircular dichroismelectronic absorption spectroscopyhorse heart cytochrome cresonance Raman spectroscopy

Identifiers

PMID41081533
PMCPMC12516914

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.