Research Communication: An Observational Cohort Study on Risk of Ovarian Cancer in Women with Irritable Bowel Syndrome.

Andrea Shin, Huiping Xu, Rachel Sarnoff, Arpana Church, Lin Chang

Abstract readObservational Study

In one paragraph

Observational study in Alimentary pharmacology & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andrea ShinVatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-7284-3398

Huiping XuDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Rachel SarnoffVatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, California, USA.

Arpana ChurchVatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, California, USA.

Lin ChangVatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles, California, USA.

Funding

The role of brain-gut microbiome interactions in mediating IBS and constipation symptoms during menses and menopauseU54DK123755 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Lin Chang, Elaine Hsiao · 2020 to 2026

$10.5M

NIDDK NIH HHS U54 DK123755NIH HHS NIH U54 DK123755

6 · The paper itself

Abstract

We compared ovarian cancer incidence between women with and without an index irritable bowel syndrome (IBS) diagnosis using administrative claims data. Risk of ovarian cancer was higher at 3 (hazard ratio [HR] = 1.71, 95% CI: 1.08-2.70, p = 0.02) and 6 (HR = 1.43, 95% CI: 1.06-1.93, p = 0.02) months after an index IBS diagnosis, but not at time points after 8 months, in women with IBS compared to those without. Some women with symptoms of ovarian cancer may be misdiagnosed with IBS, although IBS is not causally linked to ovarian cancer. Further studies are needed to validate findings and clarify when ovarian cancer screening may be warranted.

Indexed as

Irritable Bowel SyndromeOvarian NeoplasmsAdultAgedCohort StudiesFemaleHumansIncidenceMiddle AgedRisk Factors

Identifiers

PMID41081454

DOI10.1111/apt.70277

PMCPMC13147301

What OpenQuestion holds

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LicenceTDM

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.