Evidence map›Paper›PMID 41081425›Full record

ArticleBiology open2025

Comprehensive comparative analysis of the effects of temperature on the Notch signaling response in vivo.

Nimmy S John, Kah Seng Tang, Michelle A Urman, ChangHwan Lee

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nimmy S JohnDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, 12222, USA.
Kah Seng TangDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, 12222, USA.
Michelle A UrmanDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, 12222, USA.
ChangHwan LeeDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY, 12222, USA.ORCID 0000-0002-9821-9312

Funding

University at Albany 1189585-1-97969
6 · The paper itself

Abstract

Temperature is a critical factor that modulates cellular metabolism and stem cell regulation. Despite extensive studies, the influence of temperature on stem cell regulation via Notch signaling has been limited to studies relying on studies that involve indirect readouts to Notch activation. This study systematically analyzes the effects of temperature on the Notch signaling transcriptional response at the chromosomal, cellular, and tissue levels. Using complementary direct Notch readouts, we demonstrate that Notch activation remains largely unchanged across temperatures, suggesting the presence of temperature-compensatory mechanisms that maintain robust Notch activation. Notch transcriptional activity readouts, however, increased with temperature, indicating that elevated temperatures may enhance Notch transcriptional activity at the chromosomal level. These findings provide a comprehensive framework for understanding effects of temperature and offer new insights into the regulation of Notch signaling in stem cell biology.

Indexed as

Receptors, NotchSignal TransductionTemperatureAnimalsGene Expression RegulationMiceReceptors, NotchCaenorhabditis elegans gonadGradientNotch signalingSpatial pattern analysissygl-1TemperatureTranscriptional regulation

Identifiers

PMID41081425
PMCPMC12570151

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.