Evidence map›Paper›PMID 41081387›Full record

ArticleMicrobiology spectrum2025

NsrM (All0345) and NsrX (Alr1976), two FurC (PerR)-targeted transcriptional regulators, modulate nitrogen metabolism and heterocyst differentiation genes in the cyanobacterium

Jorge Guío, Marta Acero, Anindita Bandyopadhyay, Deng Liu, Himadri B Pakrasi, Isabelle Michaud-Soret, M Teresa Bes, Emma Sevilla, María F Fillat

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jorge GuíoDepartamento de Bioquímica y Biología Molecular y Celular e Instituto de Biocomputación y Física de Sistemas Complejos (Bifi), Universidad de Zaragoza, Zaragoza, Spain.
Marta AceroDepartamento de Bioquímica y Biología Molecular y Celular e Instituto de Biocomputación y Física de Sistemas Complejos (Bifi), Universidad de Zaragoza, Zaragoza, Spain.
Anindita BandyopadhyayDepartment of Biology, Washington University, St. Louis, Missouri, USA.
Deng LiuDepartment of Biology, Washington University, St. Louis, Missouri, USA.
Himadri B PakrasiDepartment of Biology, Washington University, St. Louis, Missouri, USA.ORCID 0000-0001-8240-2123
Isabelle Michaud-SoretIRIG/CEA-Grenoble, Grenoble, France.
M Teresa BesDepartamento de Bioquímica y Biología Molecular y Celular e Instituto de Biocomputación y Física de Sistemas Complejos (Bifi), Universidad de Zaragoza, Zaragoza, Spain.
Emma SevillaDepartamento de Bioquímica y Biología Molecular y Celular e Instituto de Biocomputación y Física de Sistemas Complejos (Bifi), Universidad de Zaragoza, Zaragoza, Spain.ORCID 0000-0001-6435-3540
María F FillatDepartamento de Bioquímica y Biología Molecular y Celular e Instituto de Biocomputación y Física de Sistemas Complejos (Bifi), Universidad de Zaragoza, Zaragoza, Spain.ORCID 0000-0001-8644-4574

Funding

Department of Energy Award #DE-SC0024702Gobierno de Aragón, Spain E35_23R-Biología EstructuralMinisterio de Ciencia, Eduación y Universidades, Spain PID2019-104889GB-I00, PID2023_146337NB-I00
6 · The paper itself

Abstract

The control of nitrogen metabolism in the model cyanobacterium IMPORTANCE: Filamentous, nitrogen-fixing cyanobacteria are valuable organisms for biotechnology applications and as models for the study of multicellularity in prokaryotes. Understanding the regulation of nitrogen fixation and heterocyst development is essential for optimizing their use in synthetic biology and as biofertilizers. This study identifies two novel nitrogen secondary regulators, Alr1976 (NsrX) and All0345 (NsrM), as part of the intricate regulatory circuit governing nitrogen metabolism in the model cyanobacterium

Indexed as

AnabaenaBacterial ProteinsGene Expression Regulation, BacterialNitrogenTranscription FactorsBacterial ProteinsNitrogenTranscription FactorscyanobacteriaFerric uptake regulator C (PerR)nitrogen metabolismNtcAregulatory networktranscriptional regulators

Identifiers

PMID41081387
PMCPMC12584617

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.