ArticleArtificial organs2026
Trial-Based Hemolysis Modeling to Investigate Operating Modes of Continuous-Flow LVADs.
Article in Artificial organs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe influence of operating modes on pump-induced hemolysis in continuous-flow left ventricular assist devices (LVADs) can be assessed using computational fluid dynamics (CFD) simulations alongside power law models derived from shearing device experiments. However, this conventional method incurs high computational costs, limiting the exploration of diverse operating conditions and hindering online hemolysis prediction. This work presents a CFD-free and trial-based methodology for determining online-capable hemolysis models for continuous-flow LVADs.
methodsThe trial-based hemolysis model is based on a modified power law model, with parameters identified from LVAD hemolysis trials. The dynamic behavior is modeled using the Lagrangian approach. Specifically, this model was determined for the Sputnik1 LVAD and integrated with a lumped-parameter model of the LVAD-supported cardiovascular system. Subsequently, hemolysis was predicted across various operating modes and patient conditions.
resultsThe RMSE and the R DISCUSSION: The proposed hemolysis model allows to assess various LVAD operating modes and patient conditions, assisting in the selection of low-hemolysis treatment strategies. For Sputnik1 patients, it is advisable to maintain low pump speed and systemic resistance, while speed modulation should be reserved for those with low hemolysis markers. Integrating this model with online flow sensing would enable online hemolysis prediction.
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