Evidence map›Paper›PMID 41081371›Full record

ArticleJournal of the American Chemical Society2025

Discovery and Mechanism of a Diiron Enzyme in Ethylidene Azetidine Formation.

Yaoyao Shen, Yu-Cong Zheng, Philip M Palacios, Kuo Wang, Ailiena O Maggiolo, Yisong Guo, Wei-Chen Chang

Erratum issuedAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Heme oxygenase-like dimetal oxidases and oxygenases.Biochemical Society transactions · 2026
    Review
  3. A ferritin-like diiron oxygenase BioE initiates bacterial biotin synthesis, a promising antivirulence target.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Yaoyao ShenDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.ORCID 0000-0002-1785-9001
Yu-Cong ZhengDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.ORCID 0000-0001-8509-3127
Philip M PalaciosDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.
Kuo WangDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.
Ailiena O MaggioloStanford Synchrotron Radiation Lightsource, Stanford University, Menlo Park, California 94025, United States.
Yisong GuoDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, United States.ORCID 0000-0002-4132-3565
Wei-Chen ChangDepartment of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, United States.ORCID 0000-0002-2341-9846

Funding

A Synchrotron Radiation Structural Biology ResourcesP30GM133894 · NIGMS · STANFORD UNIVERSITY · PI Ritimukta Sarangi · 2020 to 2026
$43.3M
Understanding How Nonheme Iron-Dependent Enzymes Assemble Pharmacophores: Studies of Cyclopropane, Aziridine, and Isonitrile FormationR01GM127588 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Wei-chen Chang · 2018 to 2026
$3.3M
Elucidate Mechanisms of Quinolone Alkaloid Biosynthesis via Iron(II)/2-Oxoglutarate Dependent Enzymes: Diverse, but Controlled ReactivityR01GM125924 · NIGMS · CARNEGIE-MELLON UNIVERSITY · PI Yisong Guo · 2018 to 2026
$3.3M
NIGMS NIH HHS P30 GM133894NIGMS NIH HHS R01 GM125924NIGMS NIH HHS R01 GM127588
6 · The paper itself

Abstract

Azetidine is a strained four-membered

Indexed as

AzetidinesIronOxidoreductasesCrystallography, X-RayModels, MolecularOxygenazetidineAzetidinesIronOxidoreductasesOxygen

Identifiers

PMID41081371
PMCPMC12683556

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.