ArticleJournal of cosmetic dermatology2025
Microencapsulated α-Tocopherol and Moringa Extract for Improved Skin Protection: Insights From Human Skin Assessment in Cosmetic Formulations.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Microencapsulated α-Tocopherol and Moringa Extract for Improved Skin Protection: Insights From Human Skin Assessment in Cosmetic Formulations.Journal of cosmetic dermatology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
backgroundα-Tocopherol is a potent antioxidant naturally present in human skin, protecting against oxidative damage from UV radiation and pollution. While cosmetic applications may enhance skin protection, its stability and effective delivery remain challenging. Moringa oleifera Lam. (Mo) leaves, rich in α-tocopherol and other bioactives, represent a natural alternative.
aimsTo develop and compare microcapsules containing synthetic α-tocopherol (MC α-toc) or a combination of α-tocopherol with Mo extract (MC Mo + α-toc), and to evaluate their encapsulation performance, release profile, and efficacy in cosmetic formulations. PATIENTS/
methodsMo extract was obtained by supercritical CO₂ extraction, yielding 232.5 ± 3.2 mg α-tocopherol·g
resultsMicrocapsules showed encapsulation efficiency > 93%, loading capacity ~10%, multinucleated morphology, and an average size of 60 μm. Encapsulation enhanced α-tocopherol absorption, with rates of 6% for MC α-toc and 3% for MC Mo + α-toc after 2 h, versus < 1% for nonencapsulated forms. In vivo, MC α-toc cream reduced skin spots (-25%) and brown spots (-48%), improved firmness (+47%), and increased thickness (+15%). MC Mo + α-toc cream reduced red areas (-11%) and improved transepidermal water loss (-25%).
conclusionsMicroencapsulation improved stability and delivery of α-tocopherol and Mo extract, enhancing cosmetic cream performance. Results were comparable or superior to commercial formulations, highlighting their potential for next-generation skincare products.
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Registered trials
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